The following variables were assessed at admission: the patient a

The following variables were assessed at admission: the patient age, gender, number of prescription drugs, geriatric syndromes (e. g., immobility, postural instability, dementia, depression, delirium, and incontinence), comorbidities, functional status (evaluated with the Katz Index of Independence in Activities of Daily Semaxanib Living), and severity of illness (evaluated with the Simplified Acute Physiology Score II). The incidence

of delirium, infection, mortality, and the prescription of potentially inappropriate medications (based on the Beers criteria) were assessed during hospitalization. An observer who was uninvolved in patient care reported the adverse events.

RESULTS: The mean age of the sample was 78.12 years. A total of 187 medical adverse events occurred in 94 admissions (55%). The predictors of medical adverse events were undetermined. Compared 5-Fluoracil molecular weight with the patients with no adverse events, the patients with medical adverse events had a significantly longer hospital stay (21.41 +/- 15.08 days versus 10.91 +/- 7.21 days) and a higher mortality rate (39 deaths [41.5%] versus 17 deaths [22.1%]). Mortality was significantly predicted by the Simplified Acute Physiology Score II

score (odds ratio [OR] = 1.13, confidence interval [CI] 95%, 1.07 to 1.20), the Katz score (OR = 1.47, CI 95%, 1.18 to 1.83), and medical adverse events (OR = 3.59, CI 95%, 1.55 to 8.30).

CONCLUSION: BMS-777607 in vitro Medical adverse events should be monitored in every elderly hospitalized patient because there is no risk profile for susceptible patients, and the consequences of adverse

events are serious, sometimes leading to longer hospital stays or even death.”
“Novel injection molded biocomposites were engineered from switchgrass (Panicum virgatum L) and a biodegradable matrix system. The chosen system was a pre-blend of poly(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV) and poly(butylene adipate-co-terephthalate) (PBAT). Effect of incorporation of switchgrass fiber at loading levels of 20-40 wt% was investigated. Experimental results of tensile modulus were correlated with theoretical modulus values. The hydrophobic-hydrophilic disparity between the matrix and fiber was solved by the addition of compatibilizer, poly diphenylmethane diisocyanate (pMDI). Loading levels of pMDI at 0.5, 0.75 and 1 phr were investigated. Compatibilization chemistry at the interphase has been proposed as an attempt to understand the mechanism. Remarkable improvements in mechanical property were achieved with compatibilized composites compared to the virgin composites of PHBV/PBAT/switchgrass. PHBV/PBAT matrix with 30 wt% switchgrass compatibilized by 0.75 phr pMDI resulted in the highest tensile properties and heat deflection temperature.

Assuming the presence at remanence of two populations of cylinder

Assuming the presence at remanence of two populations of cylinders with up and down magnetizations and including the dipolar coupling between the cylinders, a single analytical model based on a mean-field approach allowed us to satisfactorily analyze both series of experimental results. The model requires three physical parameters, allowing us to derive the in-plane saturation field, the eigenfrequency in the absence of applied field, and the eigenfrequency at the in-plane saturation field; these Crenigacestat Stem Cells & Wnt inhibitor parameters enable us to adjust the whole variation of the eigenfrequency versus the applied field. Moreover,

the effect of the magnetocrystalline anisotropy on the softening of the frequency in the nonsaturated state is clearly evidenced: it is more pronounced when the magnetocrystalline anisotropy

is not vanishing and adds to the shape anisotropy (Co c-axis parallel to the cylinder axis); the softening being weak in the other cases (Co c-axis perpendicular to the cylinder axis or Permalloy). (C) 2011 American Institute of Physics. [doi: 10.1063/1.3587170]“
“Background: Carbohydrate quantity and quality may play an important role in the development of type 2 diabetes.

Objective: We investigated the associations of dietary glycemic load (GL), glycemic index (GI), carbohydrate, and fiber intake with the incidence of type 2 diabetes.

Design: this website A prospective cohort study was conducted in 37,846 participants of the EPIC-NL (European Prospective Investigation into Cancer and Nutrition Netherlands) study, aged 21-70 y at baseline and free of diabetes. Dietary intake was

assessed with the use of a validated food-frequency questionnaire. Incident diabetes cases were mainly self-reported and verified against general practitioner records.

Results: During a mean follow-up of 10 y, 915 incident diabetes cases were documented. Dietary GL selleck screening library was associated with an increased diabetes risk after adjustment for age, sex, established diabetes risk factors, and dietary factors [hazard ratio (HR) per SD increase: 1.32; 95% CI: 1.14, 1.54; P < 0.001]. Cl tended to increase diabetes risk (HR: 1.08; 95% CI: 1.00, 1.17; P = 0.05). Dietary fiber was inversely associated with diabetes risk (HR: 0.92; 95% CI: 0.85, 0.99; P < 0.05), whereas carbohydrate intake was associated with increased diabetes risk (HR: 1.15; 95% CI: 1.01, 1.32; P < 0.05). Of the carbohydrate subtypes, only starch was related to increased diabetes risk [HR: 1.25 (1.07, 1.46), P < 0.05]. All associations became slightly stronger after exclusion of energy misreporters.

Conclusions: Diets high in GL, GI, and starch and low in fiber were associated with an increased diabetes risk.

Therefore, it is possible to produce natural antioxidative peptid

Therefore, it is possible to produce natural antioxidative peptides from loach protein by enzymatic hydrolysis and purification. (C) 2010 Elsevier Ltd. All rights reserved.”
“Hemichorea-hemiballism (HCHB) is an usually continuous, nonpatterned, involuntary movement disorder

caused by basal ganglia dysfunction, commonly due to a vascular lesion, described in nonketotic hyperglycemic patients. Particular computed tomography and magnetic resonance imaging findings have been described. The pathogenic mechanism of chorea arising during hyperglycemia and the nature of neuroimaging findings are unclear. LY2835219 In this paper we describe two elderly women with onset of HCHB during a hyperglycemic episode. The symptoms persisted in one of them after recovery of normal glycemia. The pathophysiological mechanism of the disease is discussed in the light of clinical selleck kinase inhibitor and neuroradiological follow-up.”
“Patients with advanced chronic kidney disease nearing dialysis but without pre-established access almost uniformly initiate dialysis with a temporary central venous catheter. These catheters are associated with high rates of infection and flow

disturbances, requiring removal and subsequent replacement. Many of these patients might be candidates for peritoneal dialysis (PD), but because of the absence of prior catheter placement, the default initial modality is hemodialysis. Recent reports, however, have demonstrated the feasibility of initiating PD urgently despite the late referral for access placement. Urgent-start PD clinical pathways require a unique infrastructure and treatment approach. This article reviews the salient features required to establish an urgent-start PD program.”
“The objective was to characterize the non-oscillatory independent components (ICs) of the auditory GDC 0032 concentration event-related potential (ERP) waveform of an oddball task for normal and newly diagnosed Alzheimer’s disease (AD) subjects, and to seek biomarkers for AD. Single trial ERP waveforms were analysed using independent

components analysis (ICA) and k-means clustering. Two stages of clustering depended upon the magnitudes and latencies, and the scalp topographies of the non-oscillatory back-projected ICs (BICs) at electrode Cz. The electrical current dipole sources of the BICs were located using Low Resolution Electromagnetic Tomography (LORETA). Generally 3-10 BICs, of different latencies and polarities, occurred in each trial. Each peak was associated with positive and negative BICs. The trial-to-trial variations in their relative numbers and magnitudes may explain the variations in the averaged ERP reported, and the delay in the averaged P300 for AD patients. The BIC latencies, topographies and electrical current density maximum locations varied from trial-to-trial. Voltage foci in the BIC topographies identify the BIC source locations.

Results: Hierarchical regression analyses revealed that those who

Results: Hierarchical regression analyses revealed that those who receive higher levels of support from others have fewer breast cancer-related concerns (b = -0.15, po0.05), while those who give higher levels of support to others reframe their own problems in a positive light and adopt more positive

strategies for coping (beta=0.16, po0.05). In addition to these positive effects, partial correlation analysis indicated that these two supportive behaviors are reciprocal. Conclusions: We concluded that supportive exchanges of receiving and giving play positive, but different, roles in predicting psychosocial health outcomes. Moreover, emotional support giving and receiving tend to reinforce each other. Our findings help practitioners, health-care providers, and health system designers make sense of diverse BVD-523 clinical trial social support processes among cancer patients participating within CMSS groups. Copyright (C) 2011 John Wiley & Sons, I-BET-762 inhibitor Ltd.”
“An ethylene-vinyl acetate (EVA) matrix containing glimepiride was prepared as a potential transdermal drug delivery system. Permeation studies of quinupramine through the EVA copolymer membrane were carried out using a two-chamber diffusion cell. The rate of drug permeation through the EVA membrane was proportional to the PEG 400 volume fraction. The release of glimepiride

from the EVA matrix was examined using a modified Franz diffusion cell. A plasticizer was added to prepare the pore structure of the EVA matrix in order to increase the rate of drug release. The effects of PEG 400, drug concentration, temperature, and plasticizer on the drug release rate were investigated. Various types of enhancers were added to an EVA matrix CH5183284 nmr containing 2% glimepiride in an attempt to increase the

level of skin permeation of quinupramine through an EVA matrix. The effects of the enhancers on the level of glimepiride permeation through the skin were evaluated using Franz diffusion cells fitted with intact excised rat skin. The rate of drug release from the EVA matrix increased with increasing PEG 400 volume fraction, temperature, and drug loading. The estimated activation energy of drug release was 7.274 kcal/mol for 2% drug loading dose. The release of glimepiride from the EVA matrix followed a diffusion-controlled model, where the quantity released per unit area was proportional to the square root of time. The controlled release of glimepiride was achieved using the EVA polymer including the plasticizer. Among the plasticizers used, such as the alkyl citrates and phthalates groups, diethyl phthalate slightly increased the rate of glimepiride release. Among the various enhancers used, such as the non-ionic surfactants, the glycerides, the propylene glycol derivatives, fatty acids (saturated or unsaturated), and pyrrolidones, linoleic acid showed the highest permeation rate; 3.17-times higher than the control.

Trials were performed

Trials were performed Daporinad using different gas flow rates (6, 8 and 10 L/min), humidification chambers (MR290, MR225) and water volumes (30g. 108g). Temperature was recorded at the humidifier chamber (T1), distal temperature probe (T2) and the T-piece (T3) over a 20 min period at 30s intervals. A test lung was added during one trial.

Results: No significant difference existed between flow rates 8L/min and 10 L/min (p = 0.091, p = 0.631). T3 reached 36 C and remained stable at 360s (8 L/min, MR225, 30 mL); near 100% RH was reached at 107 s(10 L/min, MR225, 30 mL). T3 and humidity reached and remained stable at 480 s(10 L/min, MR290, 30 mL). Target temperature and humidity was not reached

with the test lung.

Conclusions: It is possible to deliver heated, humidified gases in neonatal resuscitation in a clinically acceptable timeframe. We suggest the set-up to achieve optimal temperature and humidity for resuscitation purposes is 10 L/min of gas flow, a MR290 humidification chamber, and 30 mL of water. Crown Copyright (C) 2013 Published by Elsevier Ireland Ltd. All rights reserved.”
“Purpose

This

study was undertaken to evaluate the significance of cyclooxygenase-2 (COX2) overexpression and the expression of somatostatin receptor (SSTR) subtypes in gastroenteropancreatic neuroendocrine tumors (GEP-NETs).

Materials and Methods

Two hundred and forty-seven cases of GEP-NET, comprising

86 foregut PKC412 cost and 156 hindgut primary NETs, and 5 metastatic NETs in AL3818 mouse the liver, were studied retrospectively with immunohistochemistry for COX2, chromogranin A, Ki-67, SSTR1, SSTR2, and SSTR5.

Results

COX2 overexpression was observed in 54%(126 of 234), and SSTR1, SSTR2, and SSTR5 positivity in 84%(196 of 233), 72%(168 of 233), and 55%(128 of 232), respectively. COX2 overexpression was found to be positively correlated with Ki-67 labeling index and inversely correlated with the expression of SSTR subtypes. In addition, the expression of SSTR subtypes was tightly correlated in any comparative pairs. A significant inverse correlation was found between COX2 and SSTR2 expression in the foregut, but not hindgut NETs. Kaplan-Meier analyses showed that COX2 overexpression (p=0.003) and high Ki-67 labeling index (p < 0.001) were associated with poor overall survival (OS), whereas expression of SSTR2 (p < 0.001) was associated with better OS of GEP-NET patients. Multivariate analysis revealed negative SSTR2 expression as an independent prognostic marker in GEP-NET patients (p < 0.001).

Conclusion

Our results suggest that expression of SSTR subtypes is associated with favorable prognosis, whereas COX2 overexpression is associated with poor prognosis in GEP-NETs. Taken together, COX2 could be a possible therapeutic target in some subsets of GEP-NETs.

Scrapie-resistant genotypes were found to be uncommon, indicating

Scrapie-resistant genotypes were found to be uncommon, indicating a high risk for ovine scrapie in northwest BX-795 solubility dmso China. In addition to codons 136, 154 and 171, we found numerous new mutations; nearly half of them were previously unreported. These sheep populations have a high degree of polymorphism at the PRNP locus.”
“This paper reports the numerical simulation and experimental characterization of three-dimensional acoustic streaming behavior of a liquid droplet subjected to a Rayleigh surface acoustic wave. The streaming behavior of the droplet was studied as a function of radio-frequency (RF) power, aperture of the interdigitated transducer, and size of the liquid

droplet. The hydrodynamic flow field within the droplet was determined by solving the laminar incompressible Navier-Stoke’s equations. The numerical and experimental results are shown to be in good agreement over the range of parameters examined. The ratios of the position of butterfly central line (axis of rotation) to radius of the droplet

are demonstrated to be fairly constant for moderate droplet volumes and to vary by less than JNK-IN-8 solubility dmso 12% at large droplet volumes. Besides that, an increase in the RF power and a decrease in the droplet size result in an increased surface acoustic wave (SAW) streaming velocity. The numerical results also suggest that a maximum streaming velocity is achieved when the SAW width is approximately half of the droplet radius. (C) 2011 American Institute of Physics. [doi:10.1063/1.3586040]“
“Objectives: Children with long-standing epilepsy have a significantly increased risk of academic underachievement compared with healthy controls. We prospectively followed children from seizure onset to assess the relationship between change in neuropsychological functioning and change in academic achievement and to explore the risk and protective moderating

effects of demographic, seizure, and family variables.

Methods: As part of a larger study, neuropsychological and academic data were collected at both baseline and 36 months for 219 children 6-14 years of age with seizures. Prior factor analysis of results from a battery of well-standardized neuropsychological tests yielded four factors: language, processing speed, attention/executive/construction, Selleck 3 MA and verbal memory/learning. Academic achievement was measured with the Woodcock-Johnson Revised Achievement Test Battery. Correlation coefficients and linear mixed models were used for analysis.

Results: The reading and math scores of children with seizures and siblings did not differ at baseline, but children with seizures had lower scores than siblings at 36 months. Writing scores were significantly lower for affected children than siblings at both times. Among children with seizures, there were positive correlations between neuropsychological functioning and academic achievement at baseline and 36 months.

Meanwhile, the drug loading efficiency of microspheres and the in

Meanwhile, the drug loading efficiency of microspheres and the in vitro release of urapidil hydrochloride from microspheres were performed. The release study indicated that the urapidil hydrochloride-PLLA microspheres exhibited better sustained release capacity, and the kinetics of urapidil hydrochloride-PLLA microspheres in vitro release could be described by the Higuchi equation. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 115: 2317-2321, 2010″
“We describe an irrigating iris retractor for cataract surgery in eyes with small pupils. The retractor, a modified irrigating handpiece, has 2 standard side-port irrigating openings and a smooth, button-like iris hook in the front. The hook is

inserted Smad inhibitor into the margin of a small pupil and retracts the pupil peripherally to allow visualization of cortical remnants in the equatorial area of the lens capsule. The capsule can then be safely cleaned using the aspirating handpiece in the surgeon’s other hand.”
“S100A1, a small EP-hand Ca(2+)-binding protein with intracellular and extracellular functions, is predominantly expressed in cardiac muscle where it plays a crucial role as a modulator of Ca(2+) homeostasis, energy metabolism and contractile performance. Essentially, its beneficial effects on heart function have GDC-0973 MAPK inhibitor been attributed to its direct interaction with, and effects on, sarcoplasmic

reticulum calcium handling proteins sarco(endo) plasmic reticulum Ca(2+) ATEase and the ryanodine receptor. Downregulated

levels of S100A1 in cardiomyocytes postmyocardial infarction have been linked to diminished cardiac reserve and contribute to the development of heart failure. Interestingly, S100A1 expression has recently been described in endothelial cells where it is downregulated in heart failure and has been shown tit modulare intracellular Ca(2+). levels and nitric oxide production. Absence of the Ca(2+) sensor protein in endothelial cells is associated with endothelial dysfunction and hypertension. Thus, S100A1 is emerging its a potential therapeutic target for diverse cardiovascular conditions.”
“In this paper, an effective and green strategy was developed to obtain aglycone isoflavones from soybean through the extraction, hydrolysis, and purification steps. Firstly, a novel ethanol-alkaline extraction method was designed and optimized. Rapamycin datasheet The high extraction yield (94.34%) of isoflavones was achieved under the optimal extraction conditions of pH 9.0, 70A degrees C, 60 min, ethanol concentration of 65%, and 1:15 of the solid to liquid ratio. Then, the cellulase (GC-220) was used instead of traditional beta-glucosidase to hydrolyze the glycoside isoflavones into aglycone isoflavones which gave an excellent conversion of 95%. Finally, the crude aglycone isoflavones have been purified by an environmental-friendly procedure comprised of ethanol precipitation, ethyl acetate extraction, and water rinse. The final amount of aglycone isoflavones obtained was 1.

PZT 90/10 and PLZT 2/90/10 undergo two phase transitions, from a

PZT 90/10 and PLZT 2/90/10 undergo two phase transitions, from a cubic paraelectric to a rhombohedral untilted ferroelectric (FE) phase and on further cooling to a tilted FE phase. PLZT 4/90/10 and PLZT 10/90/10 are incommensurately modulated and composed of an intergrowth of polar and antipolar

cation displacements. These samples consequently demonstrate a FE soft mode which exhibits minimal frequency several tens of degrees above the nominal antiferroelectric phase transition temperature. The dielectric response of PLZT 100x/90/10 is mainly governed by a gigahertz relaxation and a soft phonon component in the THz range. As in other PbO-based perovskites, the soft mode is split into a higher-frequency component (omega similar to 80 cm(-1)) and a highly damped Selleckchem CBL0137 THz component (omega similar to 30 cm(-1)), with larger dielectric strength already in the paraelectric phase. (C) 2010 American Institute of Physics. [doi:10.1063/1.3501105]“
“High-resolution synchrotron x-ray diffraction and field emission-scanning electron microscopy were used to investigate domain structures of the unpoled (001)-oriented 89.5% Pb (Zn1/3Nb2/3)O-3- 10.5%PbTiO3 (PZN-10.5% PT) single crystal. The results revealed the coexistence of 180 and

90 degrees tetragonal nanotwin domains at room temperature. Upon zero-field heating, the PZN-10.5% PT undergoes a tetragonal-to-cubic Smoothened Agonist in vitro transformation near 185 degrees C. Tetragonal PZN-10.5% PT crystal has better thermal stability notably in the temperature range of 80-150 degrees C. This makes the tetragonal PZN-PT potential

candidates for high temperature piezoelectric devices. (C) 2010 American Institute of Physics. [doi:10.1063/1.3505638]“
“Objective:

The reduced intensity conditioning (RIC) stem cell transplantation is widely employed for the treatment of many hematologic malignancies, but the survival effectiveness is still unclear. This study conducted an updated meta-analysis to determine whether any significant difference could be found by using RIC vs. myeloablative conditioning (MAC) regimen LB-100 inhibitor for transplantation in patients with malignancies.

Methods:

We electronically searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, and relevant articles (1987.01-2009.12). Comparative studies were carried out on clinical therapeutic effect of RIC and MAC on the survival outcomes and the transplantation-related complications.

Results:

We obtained 1776 records, and 29 studies totaling 6235 patients have been assessed. Compared with MAC regimen, the RIC regimen had a higher overall survival (OS) at one-yr and no difference at two-yr later after transplantation. RIC regimen had significantly lower rates of disease-free survival (DFS) after two-yr follow-up, lower incidences of >= II degree acute graft-versus-host disease (aGVHD), and lower TRM [OR, 0.61, 95% CI (0.53, 0.69)], but with a higher relapse rate [OR, 1.88(1.41, 2.51)].

Results: Data for 245 consecutive patients were collected

Results: Data for 245 consecutive patients were collected.

Thirty nine patients (15.9%) survived for more than 2 years. Long-term survivors were more likely to have had metastases at fewer sites (P = 0.008), an absence of bone metastases (P = 0.01), a performance status (PS) of 0-1 at first progression of the tumour (P = 0.002), a tumour that was controlled with first (P < 0.0001) andsecond-line (P = 0.004) chemotherapy, maintenance therapy (P = 0.001), curative surgery (P < 0.0001), time to first progression of the tumour of > 3 months (P < 0.0001), normal LDH levels at diagnosis (P = 0.049), and a haemoglobin concentration > 110 g/L at first progression of the Alvocidib tumour (P = 0.02). In multivariate analysis, surgery, maintenance treatment, time to first progression of the tumour of > 3 months, a PS of 0-1 at first progression, the number of chemotherapy agentsreceived, and LDH levels, weresignificantpredictors of long-termsurvival.

Conclusions: Assessment of these factors, and the use of maintenance therapy, when possible, may identify a population of patients with NSCLC that is likely to have a prolonged life expectancy.”
“Introduction: 2,4,6-trinitrotoluene (TNT) has been

widely used as an explosive. TNT can induce some well-recognized toxic impacts comprising toxic hepatitis, aplastic anemia and cataract. The aim of study was evaluation of TNT exposed workers for systemic complication.

Methods: In a cross-sectional study, we carried out Liver Function Test (LFT),

Fer-1 complete blood count (CBC) and slit lamp biomicroscopy to compare the prevalence and severity of these 3 complications between 47 male TNT exposed workers (with at least one year continuous experience of TNT exposure) and 43 unexposed male hospital worker who hadn’t had any previous contacts with TNT. We also performed Pulmonary Function Test (PFT) to assess the probable obstructive/restrictive abnormalities, PCI 32765 caused by TNT.

Results: Mean alkaline phosphatase (ALP) level of TNT exposed group was significantly higher than the unexposed group (p = 0.023) Forced Expiratory Volume in one second to Forced Vital Capacity (FEV1/FVC) ratios of both groups were in the range of restrictive pattern (82.03% and 81.42% for the exposed and unexposed group, respectively) with no meaningful difference. We didn’t find out any specific TNT induced cataract and general cortical cataract (CC) and nuclear sclerotic cataract (NSC) prevalence was not significantly different.

Discussion: we haven’t found TNT as a chemical, causing toxic hepatitis or aplastic anemia; neither did we find it as a compound, responsible for a meaningful increase in cataract prevalence. However, due to the increased ALP serum levels and FEV1/FVC ratios among TNT workers, safety precautions are advised.”
“Anxiety and depression leads to a number of morbid states. Search of new agents which are low-priced and safe alternative is necessary.

(C)

2009 Wiley Periodicals, Inc J Appl Polym Sci 115: 33

(C)

2009 Wiley Periodicals, Inc. J Appl Polym Sci 115: 3303-3310, 2010″
“Cerebral cavernous malformations (CCMs) are vascular abnormalities that may cause seizures, headaches, intracerebral hemorrhages, and focal neurological deficits; they can also be clinically silent and may occur as a sporadic or an autosomal dominant condition. Three genes have been identified as causing familial CCM: KRIT1/CCM1, MGC4607/CCM2, and PDCD10/CCM3, mapping, respectively, on chromosomes 7q, 7p, and 3q. This is a report Sapitinib nmr on an Italian family affected by CCM due to a KRIT1 gene mutation on exon 13. The mother suffered from a cerebellar hematoma and was severely disabled; one son had suffered from intractable seizures and underwent surgery

for removal selleck chemical of a cavernous angioma, while another son was asymptomatic. Brain MRI showed CCMs in all patients. This report underlines that a familial form of CCM could be suspected when a patient presents with multiple CCMs; neurologists and neurosurgeons should be aware that genetic testing for these forms is available.”
“Interest exists in the manufacture of functional meat products whereby synthetic antioxidants are replaced with naturally-sourced compounds. Therefore the aim of this study was to determine the bioactivity of pork and beef patties containing ellagic acid (600 mu g/g), lutein (200 mu g/g) or sesamol (500 mu g/g). Cooked pork and beef patties were subjected to an in vitro digestion procedure and the resultant micelles were added to human intestinal Caco-2 cells. Supplementation with micelles from lutein-enriched pork patties protected (P < 0.05) against H(2)O(2)-induced cell injury whereas the presence of control beef, lutein-enriched beef or ellagic acid-enriched beef, at levels >= 20% (v/v), enhanced (P < 0.05) oxidant-induced cytotoxicity. None of the pork patties significantly BEZ235 modulated cellular

glutathione content. Micelles from all the enriched pork patties significantly protected against H(2)O(2)-induced DNA damage. In conclusion, the cytoprotective and genoprotective effects of ellagic acid, lutein, and sesamol, when incorporated into meat systems, depend greatly on the food matrix. (C) 2009 Elsevier Ltd. All rights reserved.”
“The radio-frequency plasma-initiated polymerization of N-isopropylacrylamide (NIPAM) in the solid state was performed. The isolated linear polymer was characterized by (13)C-NMR, (1)H-NMR, and Fourier transform infrared spectroscopy, and the effects of selected operational plasma parameters (discharge power and time) on the conversion rates were studied. Reversible transitions at the volume-phase-transition temperatures of the swelled poly(N-isopropylacrylamide) hydrogels were investigated by differential scanning calorimetry. The surface morphologies before and after plasma treatment were followed by scanning electron microscopy.