Pure neuronal cultures, derived from foetal BALB/c mice cortices, were provoked into injury PF-6463922 by oxygen and glucose deprivation (OGD). Cultures were exposed to either nitrogen hypoxia or noble gas hypoxia in balanced salt solution devoid of glucose for 90 min. The cultures were allowed to recover
in normal culture medium for a further 24 h in nitrogen or noble gas. The effect of noble gases on cell reducing ability in the absence of OGD was also investigated. Cell reducing ability was quantified via an MITT assay and expressed as a ratio of the control. The OGD caused a reduction in cell reducing ability to 0.56 +/- 0.04 of the control in the absence of noble gas (p < 0.001). Like xenon (0.92 +/- 0.10; p < 0.001), neuroprotection was Afforded by argon (0.71 +/- 0.05; BAY 11-7082 concentration p < 0.01). Neon and krypton did not have a protective effect under our experimental conditions. Helium had a detrimental effect on the cells. In the absence of OGD, krypton reduced the reducing ability of uninjured cells to 0.84 +/- 0.09 (p < 0.01), but argon showed an improvement in reducing ability to 1.15 +/- 0.11 (p < 0.05). Our data suggest that the cheap and widely available noble gas argon may have potential as a neuroprotectant
for the future. (C) 2009 Elsevier Ireland Ltd. All rights reserved.”
“Resting frontal electroencephalographic (EEG) alpha-asymmetry was measured in 16 participants to predict affective responses to musical stimuli. Three affective musical stimuli either expressing neutral, positive or negative mood were evaluated by the subjects concerning “”expressed mood”" and “”level of enjoyment”". The results show that individuals with relatively higher Avelestat (AZD9668) alpha power over right frontal electrode sites rated all stimuli more positive than participants with relatively higher alpha power over left frontal electrode sites. On the “”expressed mood”" scale, the valence of the stimuli did not influence
the difference between the ratings of left- and right-active individuals. On the “”enjoyment”" scale, the largest difference between the ratings of left- and right-active individuals emerged in the negative condition. The results are specific to the alpha frequency band. In line with previous studies, these results suggest that resting frontal alpha-asymmetry reflects a person’s predisposition to respond affectively. (C) 2009 Elsevier Ireland Ltd. All rights reserved.”
“Background Prophylaxis for venous thromboembolism is recommended for at least 10 days after total knee arthroplasty; oral regimens could enable shorter hospital stays. We aimed to test the efficacy and safety of oral rivaroxaban for the prevention of venous thromboembolism after total knee arthroplasty.