Results: Data for 245 consecutive patients were collected.
Thirty nine patients (15.9%) survived for more than 2 years. Long-term survivors were more likely to have had metastases at fewer sites (P = 0.008), an absence of bone metastases (P = 0.01), a performance status (PS) of 0-1 at first progression of the tumour (P = 0.002), a tumour that was controlled with first (P < 0.0001) andsecond-line (P = 0.004) chemotherapy, maintenance therapy (P = 0.001), curative surgery (P < 0.0001), time to first progression of the tumour of > 3 months (P < 0.0001), normal LDH levels at diagnosis (P = 0.049), and a haemoglobin concentration > 110 g/L at first progression of the Alvocidib tumour (P = 0.02). In multivariate analysis, surgery, maintenance treatment, time to first progression of the tumour of > 3 months, a PS of 0-1 at first progression, the number of chemotherapy agentsreceived, and LDH levels, weresignificantpredictors of long-termsurvival.
Conclusions: Assessment of these factors, and the use of maintenance therapy, when possible, may identify a population of patients with NSCLC that is likely to have a prolonged life expectancy.”
“Introduction: 2,4,6-trinitrotoluene (TNT) has been
widely used as an explosive. TNT can induce some well-recognized toxic impacts comprising toxic hepatitis, aplastic anemia and cataract. The aim of study was evaluation of TNT exposed workers for systemic complication.
Methods: In a cross-sectional study, we carried out Liver Function Test (LFT),
Fer-1 complete blood count (CBC) and slit lamp biomicroscopy to compare the prevalence and severity of these 3 complications between 47 male TNT exposed workers (with at least one year continuous experience of TNT exposure) and 43 unexposed male hospital worker who hadn’t had any previous contacts with TNT. We also performed Pulmonary Function Test (PFT) to assess the probable obstructive/restrictive abnormalities, PCI 32765 caused by TNT.
Results: Mean alkaline phosphatase (ALP) level of TNT exposed group was significantly higher than the unexposed group (p = 0.023) Forced Expiratory Volume in one second to Forced Vital Capacity (FEV1/FVC) ratios of both groups were in the range of restrictive pattern (82.03% and 81.42% for the exposed and unexposed group, respectively) with no meaningful difference. We didn’t find out any specific TNT induced cataract and general cortical cataract (CC) and nuclear sclerotic cataract (NSC) prevalence was not significantly different.
Discussion: we haven’t found TNT as a chemical, causing toxic hepatitis or aplastic anemia; neither did we find it as a compound, responsible for a meaningful increase in cataract prevalence. However, due to the increased ALP serum levels and FEV1/FVC ratios among TNT workers, safety precautions are advised.”
“Anxiety and depression leads to a number of morbid states. Search of new agents which are low-priced and safe alternative is necessary.