4 mm; p=0.02) compared with more shallow lesions.\n\nConclusions Bone erosions in RA patients treated with TNFi show

evidence of limited repair in contrast to bone erosions in patients treated with methotrexate. Repair is associated with a decrease in the depth of lesions and sclerosis at the bases of the lesions. Repair thus emerges from the endosteal rather than periosteal bone compartment and probably involves the bone marrow.”
“Protein refolding VX-809 is an important process to obtain active recombinant proteins from inclusion bodies (protein aggregates). However, the conventional refolding method of dialysis or dilution is a time consuming procedure and often, recovering yields of active proteins are low. In this study, we used controllable diffusion through laminar flow in microchannels to control

the denaturant concentration. The performance of the designed microfluidic chips was evaluated by the refolding of difficult-to-fold proteins (citrate synthase and the zeta-associated protein 70-kDa protein kinase domain). We demonstrated this by varying the flow rates of the diluting buffer stream(s) and multi-junctions which could FG 4592 control the different flow rate ratios of the buffer stream(s) and the denatured protein stream. By this strategy, we were able to improve the efficiency of protein refolding. Our method achieved refolding within a short period of time at room temperature without the need of any small molecules or chaperone proteins.

Moreover, the efficiency of protein refolding by microfluidic chip was found higher than that prepared by dialysis or dilution. These results suggest that microfluidic chips employing this strategy may provide miniaturized tools for rapid and efficient recovery of active proteins from inclusion bodies.”
“Abnormalities in limbic-thalamic-cortical networks are hypothesized to modulate human mood states In the present study differences in hippocampal volumes of patients with a first episode of depression, recurrent major depression and healthy control subjects were examined with high-resolution magnetic resonance imaging (MRI). Male patients with a first episode of major depression had a significantly smaller left hippocampal volume selleckchem than male control subjects. Also, these patients had a significant left-right asymmetry in hippocampal volume. Female patients showed no significant alterations in hippocampal volumes. The results support the hypothesis that the hippocampus plays an important role in the pathophysiology of the early phase of major depression, especially for male patients. Implications for the neurodevelopmental and the neurodegenerative model of hippocampal change are discussed. (C) 2008 Elsevier Ireland Ltd. All rights reserved.”
“Logic circuits capable of operating at high temperatures can alleviate expensive heat-sinking and thermal-management requirements of modern electronics and are enabling for advanced propulsion systems.

Finally, we found that Foxp3 bound to IL-21P and the CNS-2 enhancer and inhibited c-Maf-induced IL-21 production modestly but significantly in CD4(+) T cells. Taken together,

these results suggest that c-Maf induces IL-21 production directly in CD4(+) T cells JQ1 research buy by activating IL-21P and the CNS-2 enhancer and that TGF-beta suppresses c-Maf-induced IL-21 production in CD4(+) T cells. J. Leukoc. Biol. 87: 703-712; 2010.”
“Chemokines and their receptors play a critical role in orchestrating the immune response during experimental autoimmune encephalomyelitis (EAE). Expression of CCR4 and its ligand CCL22 has been observed in ongoing disease. Here we describe a role for CCR4 in EAE, illustrating delayed and decreased disease incidence in CCR4(-/-) mice corresponding with diminished CNS infiltrate. Peripheral T cell responses were unaltered in CCR4(-/-) mice; rather, disease reduction was related to reduced CD11b(+)Ly6C(hi) inflammatory macrophage (iW phi) numbers and function. These results provide evidence that CCR4 regulates EAE development and further supports the involvement of CCR4 in iM phi effector function. (C) 2011 Elsevier B.V. All rights reserved.”
“Rationale: Clinical studies show that flexible dosing (maintenance and symptom-driven dose adjustments) of budesonide and formoterol (BUD/FORM) improves control of asthma exacerbations as compared to fixed

maintenance dosing protocols selleck screening library (maintenance therapy) even when the latter utilize higher BUD/FORM doses. This SBE-β-CD molecular weight suggests that dose-response relationships for certain pathobiologic mechanisms in asthma shift over time. Here, we have conducted animal studies to address this issue.\n\nObjectives: (1) To test in an animal asthma-like model whether it is possible to achieve the same or greater pharmacological

control over bronchoconstriction and airway/lung inflammation, and with less total drug used, by flexible BUD/FORM dosing (upward adjustment of doses) in association with allergen challenges. (2) To determine whether the benefit requires adjustment of both drug components.\n\nMethods: Rats sensitized on days 0 and 7 were challenged intratracheally with ovalbumin on days 14 and 21. On days 13-21, rats were treated intratracheally with fixed maintenance or flexible BUD/FORM combinations. On day 22, rats were challenged with methacholine and lungs were harvested for analysis.\n\nResults: A flexible BUD/FORM dosing regimen (using 3.3 times less total drug than the fixed maintenance high dose regimen), delivered the same or greater reductions of excised lung gas volume (a measure of gas trapped in lung by bronchoconstriction) and lung weight (a measure of inflammatory oedema). When either BUD or FORM alone was increased on days of challenge, the benefit of the flexible dose upward adjustment was lost.

Statistical analysis: significant variation pre and post-intervention; paired Student’s t test or Wilcoxon’s test; existence of a significant difference between the two groups; Student’s t test for independent

samples or Mann-Whitney test. comparison among three groups: analysis of variance (ANOVA) or Kruskal-Wallis.\n\nResults: Cholesterol, LDL, triglycerides, body mass index, Castelli indexes 1 awl 11 and waist circumference showed a significant decrease, even in patients without hypolipemiant treatment. The assessment of the Transmembrane Transporters inhibitor diet impact showed that 72% of the patients that did not follow a diet, started to do so. Physical activity: of the 55% sedentary patients, 71% started to exercise three or more times a week. Smoking: of the smokers, 60% (9% of the total) Citarinostat inhibitor stopped smoking and 32% decreased the number of cigarettes.\n\nConclusion: These results demonstrated the effectiveness of the programs to improve life habits when applied to the units of the public health system. (Arq Bras Cardiol 2010;94(6): 68 5-692)”
“Derivatization of poly(benzimidazole) (PBI) with methyl groups generates poly(dimethyl benzimidazolium)

(PDMI), an anion exchange material. By using a simple ion exchange process, it is possible to produce PDMI salts with a variety of counter-ions. Anionic conductivity (2.7 +/- 0.33 to 8.5 +/- 0.5 x 10(-3) S cm(-1)) for the PDMI membranes was found to be surprisingly high even though the membranes generally exhibit very low water uptakes. To the best of our knowledge, this represents the first report on the anionic conductivity of poly(dialkyl benzimidazolium) salts, despite the large body of literature on PBI and on molecular imidazolium salts.”
“Data on natural enemies of psyllids are rare and can usually be found in papers about economically significant species. During an investigation of psyllid fauna in Serbia, natural enemies were investigated, too. True bugs were the most numerous among them. From 28 psyllid species,

21 species of true bugs from families Anthocoridae and Miridae www.selleckchem.com/products/ly3039478.html were reared. Seven species of Anthocoridae were identified: Anthocoris amplicollis (Horvath, 1839), A. confusus Reuter, 1884, A. nemoralis (Fabricius, 1794), A. nemorum (Linnaeus, 1761), Orius majusculus Reuter, 1884, O. minutus (Linnaeus, 1758) and O. niger Wolff, 1811. The following 14 species of Miridae were identified: Atractotomus mali Meyer-Dur, 1843, Campylomma verbasci (Meyer-Dur, 1843), Deraeocoris flavilinea (A. Costa, 1862), D. ruber (Linnaeus, 1758), D. lutescens (Schilling, 1836), Heterocordylus genistae (Scopoli, 1763), Hypseloecus visci (Puton, 1888), Malacocoris chlorizans Panzer, 1794, Miris striatus (Linnaeus, 1758), Orthotylus marginalis Reuter, 1884, Psallus assimilis Stichel, 1956, Ps. quercus Kirschbaum, 1856, Ps. flavellus Stichel, 1933 and Pseudoloxops coccinea (Meyer-Dur, 1843).

Methods: The anxiolytic activity was evaluated with the adult mice by hole board test, and the light-dark

box test, and motor coordination with the rota rod test. The efficacy of the plant extract (100-400 mg/kg) was compared with the standard anxiolytic drug diazepam (1 mg/kg i.p.) Results: The extract increased the time spent in the brightly-lit chamber of the light/dark box, as well as in the number of times the animal crossed from one compartment to the other. Performance on the rota rod was unaffected. In the hole SB273005 board test, the extract significantly increased both head-dip counts and head-dip duration. Urtica urens, in contrast to diazepam, had no effect on locomotion. Conclusions: These results provides support for anxiolytic activity Fludarabine research buy of Urtica urens, in line with its medicinal traditional use, and may also suggest a better side-effect profile of Urtica urens relative to diazepam.”
“The aim of the study is to investigate transient receptor potential ankyrin 1 (TRPA1)-induced responses in the vasculature and on blood pressure and heart rate (HR), in response to TRPA1 agonists using wild-type (WT) and TRPA1 knockout (KO) mice.\n\nTRPA1 agonists allyl isothiocyanate and

cinnamaldehyde (CA) significantly increased blood flow in the skin of anaesthetized WT, but not in TRPA1 KO mice. CA also induced TRPA1-dependent relaxation of mesenteric arteries. Intravenously injected CA induced a transient hypotensive response accompanied by decreased HR that was, depending on genotype and dose, followed by a more sustained dose-dependent pressor response (10-320 Selleckchem SHP099 mu mol/kg). CA (80 mu mol/kg)

induced a depressor response that was significantly less in TRPA1 KO mice, with minimal pressor effects. The pressor response of a higher CA dose (320 mu mol/kg) was observed in WT but not in TRPA1 KO mice, indicating involvement of TRPA1. Experiments using TRP vanilloid 1 (TRPV1) KO and calcitonin gene-related peptide (CGRP) KO mice provided little evidence for the involvement of TRPV1 or CGRP, nor did blocking substance P receptors affect responses. However, the cholinergic antagonist atropine sulphate (5 mg/kg) significantly inhibited the depressor response and slowed HR with CA (80 mu mol/kg), but had no effect on pressor responses. The pressor response remained unaffected, even in the presence of the ganglion blocker hexamethonium bromide (1 mg/kg). The alpha-adrenergic blocker prazosin hydrochloride (1 mg/kg) significantly inhibited both components, but not slowed HR.\n\nTRPA1 is involved in mediating vasodilation. TRPA1 can also influence changes in blood pressure of possible relevance to autonomic system reflexes and potentially to vasovagal/neurocardiogenic syncope disorders.”
“Ants of the tribe Attini are characterized by their obligate cultivation of symbiotic fungi.

AFR was considered dependent variable in the three regressions. Relation between AFR x SCNS resulted in a higher coefficient of determination (0.87). Leaf area estimated by the equation Nirogacestat order obtained from AFR x SCNS relation was 87% accurate, according to AFR x AFE (estimated leaf area) relation. Therefore, leaf area from grapevine ‘BRS-Violeta’ cultivar can be estimated by the equation: y = 0.2169 (SCNS)(2) + 5.3642 (SCNS) – 34.725, with adequate accuracy.”
“The flow of energy and nutrients between trophic levels is affected by both

the trophic structure of food webs and the diversity of species within trophic levels. However, the combined effects of trophic structure and diversity on trophic transfer remain largely unknown. Here we ask whether changes in consumer diversity have the same effect as changes in resource diversity on rates of resource consumption. We address this question by focusing on consumer-resource dynamics find more for the ecologically important process of decomposition. This study compares the top-down effect of consumer (detritivore) diversity on the consumption of dead organic matter (decomposition)

with the bottom-up effect of resource (detrital) diversity, based on a compilation of 90 observations reported in 28 studies. We did not detect effects of either detrital or consumer diversity on measures of detrital standing stock, and effects on consumer standing stock were equivocal. However, our meta-analysis indicates that reductions in detritivore diversity result in significant reductions in the rate of learn more decomposition. Detrital diversity has both positive and negative effects on decomposition, with no overall trend. This difference between top-down and bottom-up effects of diversity is robust to different effect size metrics and could not be explained by differences in experimental systems or designs between detritivore and detrital manipulations. Our finding that resource diversity

has no net effect on consumption in “brown” (detritus-consumer) food webs contrasts with previous. ndings from “green” (plant-herbivore) food webs and suggests that effects of plant diversity on consumption may fundamentally change after plant death.”
“Three series of 6,7-dimethoxyquinazoline derivatives substituted in the 4-position by aniline, N-methylaniline and aryloxy entities, targeting EGFR and VEGFR-2 tyrosine kinases, were designed and synthesized. Pharmacological activities of these compounds have been evaluated for their enzymatic inhibition of VEGFR-2 and EGFR and for their antiproliferative activities on various cancer cell lines. We have studied the impact of the variation in the 4-position substitution of the quinazoline core. Substitution by aryloxy groups led to new compounds which are selective inhibitors of VEGFR-2 enzyme with IC(50) values in the nanomolar range in vitro.

“
“Primary

objective: The purposes of this paper are to review: (1) the history of chronic traumatic encephalopathy (CTE) in sports, (2) the similarities and differences between historic and current definitions of CTE, (3) recent epidemiology and cohort studies of CTE and (4) controversies regarding the current CTE positions. Research design: see more Not applicable. Methods and procedures: Selective review of published articles relevant to CTE. Main outcome and results: The current definitions of CTE have evolved from its original definition and now rely heavily on the post-mortem detection of hyperphosphorylated tau for diagnosis. As of 2013, there is a blended cohort of 110 professional athletes diagnosed with CTE. It is being assumed that concussions and/or sub-concussive impacts in contact sports are the sole cause of CTE. Conclusions:

There are multiple causes of abnormal tau protein deposition in the human brain and the pathogenesis of CTE may not be related solely to concussion and/or sub-concussive injury. In all likelihood, the causes of CTE are a multivariate, as opposed to a univariate, phenomenon.”
“P>Low steady state haemoglobin oxygen saturation in MRT67307 patients with sickle cell anaemia has been associated with the degree of anaemia and haemolysis. How much pulmonary dysfunction contributes to low saturation is not clear. In a prospective study of children and adolescents with sickle cell disease aged 3-20 years at steady state and matched controls, 52% of 391 patients versus 24% of 63 controls had steady state oxygen saturation < 99% (P < 0 center dot 0001), 9% of patients versus no controls had saturation

< 95% (P = 0 center dot 008) and 8% of patients versus no controls had exercise-induced reduction in saturation >= 3%. Decreasing haemoglobin concentration (P < 0 center Galardin dot 001) and increasing haemolysis (P < 0 center dot 003) but not pulmonary function tests were independent predictors of both lower steady-state saturation and exercise-induced reduction in saturation. Neither history of stroke nor history of acute chest syndrome was significantly associated with lower steady-state oxygen saturation or exercise-induced reduction in saturation. Tricuspid regurgitation velocity was higher in patients with lower steady state haemoglobin oxygen saturation (P = 0 center dot 003) and with greater decline in oxygen saturation during the six-minute walk (P = 0 center dot 022). In conclusion, lower haemoglobin oxygen saturation is independently associated with increasing degrees of anaemia and haemolysis but not pulmonary function abnormalities among children and adolescents with sickle cell disease.”
“The membrane domain of human erythrocyte anion exchanger 1 (AE1) works as a C1(-)/HCO(3)(-) antiporter This exchange is a key step for CO(2)/O(2) circulation in the blood.

In addition, the shared variance between stability measures, step kinematics, and trunk kinematics is reported. The stability measures included the anteroposterior distance (d) between the body center of mass and the stepping limb toe, the margin of stability (MOS), as well as time-to-boundary considering velocity (TTB(nu)), velocity and acceleration (TTB(a)), selleck chemical and MOS (TTB(MOS)). Kinematic

measures included trunk flexion angle and angular velocity, step length, and the time after disturbance onset of recovery step completion. Fourteen young adults stood on a treadmill that delivered surface accelerations necessitating multiple forward compensatory steps. Thirteen subjects fell from an initial disturbance, but recovered from a second, identical disturbance. Trunk flexion velocity at completion of the first recovery step and trunk flexion angle at completion of the second step had the greatest overall classification of all measures (92.3%). TTB(nu) and TTB(a) at completion of both steps had the greatest classification accuracy of all stability measures (80.8%). The length of the first recovery step (r <= 0.70) and trunk flexion angle at completion of the second recovery step (r <= -0.54) had the largest correlations with stability measures. Although

TTB(nu) and TTB(a) demonstrated somewhat smaller discriminant capabilities than trunk kinematics, the small correlations between these stability measures and trunk kinematics (vertical bar r vertical bar <= 0.52) suggest that they reflect two important, yet different, aspects of a compensatory stepping response. (C) 2011 Elsevier Ltd. All rights reserved.”
“In the title Selleckchem SNX-5422 compound, C(11)H(17)NO(2)S, the molecules interact in a head-to-tail fashion through pairs of Selleckchem CP 868596 N-H center dot center dot center dot O hydrogen bonds, giving discrete centrosymmetric dimers. The N(H)S(O)(t)Bu fragment

is disordered over two sets of positions, with the major component comprising 90.0 (2)%.”
“This article reviews the current position of phenobarbital using articles published since 2000 and speculates on its likely future contribution to epilepsy care. Over the last decade there have been no major double-blind randomized placebo-controlled or comparative trials with phenobarbital. Previous studies have suggested that phenobarbital is as effective in monotherapy as phenytoin and carbamazepine. Several observational studies undertaken in developing countries over the last decade have confirmed its efficacy and safety for the common epilepsies. This was particularly so in the substantial demonstration project undertaken in rural China under the auspices of the World Health Organization in partnership with the International League Against Epilepsy and International Bureau for Epilepsy. Phenobarbital is still widely used for neonatal and childhood seizures and for drug-resistant convulsive and nonconvulsive status epilepticus.

Mixing a single-site acting fungicide with a multi-site acting fungicide delayed the emergence of resistance to the single-site component. Combining the findings with previous work on the selection phase will enable us to develop more efficient anti-resistance strategies.”
“Formal evaluation of hospital performance in specific

types of care is becoming an indispensable tool for quality assurance in the health care system. When the prime concern lies in reducing the risk of a cause-specific event, we propose to evaluate performance in terms of an average excess cumulative incidence, referring to the center’s observed patient mix. Its intuitive interpretation helps give meaning to the evaluation results and facilitates the determination

of important benchmarks for hospital performance. We apply it to the evaluation of cerebrovascular RepSox TGF-beta/Smad inhibitor deaths after stroke in Swedish stroke centers, using data from Riksstroke, the Swedish stroke registry. Copyright (c) 2015 John Wiley & Sons, Ltd.”
“Experimental evidence suggests that the healing of diabetic foot ulcers is affected by psychosocial factors such as distress. We examined this proposal in a prospective study, in which we considered the role of psychological distress and coping style in the healing of diabetic foot GSI-IX supplier ulcers over a 24 week period. We also explored the role of salivary cortisol and matrix metalloproteinases (MMPs) as potential mechanisms.\n\nFor this prospective observational study we recruited 93 (68 men; mean age 60 years) patients with neuropathic or neuroischaemic diabetic foot ulcers from specialist SN-38 podiatry clinics in secondary care. Clinical and demographic determinants of healing, psychological distress, coping, salivary cortisol and both MMP2 and MMP9 were assessed at baseline. Ulcers were assessed at baseline and at 6, 12 and 24 weeks post-baseline. The primary outcome was ulcer status at 24 weeks, i.e. healed vs not healed.\n\nAfter controlling

for clinical and demographic determinants of healing, ulcer healing at 24 weeks was predicted by confrontation coping, but not by depression or anxiety. Patients with unhealed ulcers exhibited greater confrontation coping (model including depression: OR 0.809, 95% CI 0.704-0.929, p = 0.003; model including anxiety: OR 0.810, 95% CI 0.704-0.930, p = 0.003). However, change in ulcer size over the observation period was associated with depression only (p = 0.04, d = 0.31). Healed ulcers by 24 weeks were also associated with lower evening cortisol, higher precursor MMP2 and a greater cortisol awakening response.\n\nConfrontation coping and depression predict ulcer healing. Our preliminary enquiry into biological mechanisms suggests that cortisol and precursor MMP2 may underlie these relationships.

Furthermore, we present the

oldest illustration of this pathological condition, published in a book by Carl Wenzel in 1824. Extraforaminal entrapment of the spinal nerve in transitional lumbosacral segment with unilateral transverse process anomaly can cause radiculopathy, and osteophytes are see more the cause of the entrapment. Dysplastic facet joints on the level below the transitional vertebra could be one reason for “micromotion” resulting in pseudoarthrosis with osteophytes. Sciatica relief was obtained by means of selective nerve root blocks or posterior decompression via a dorsomedial approach.”
“Title.\n\nThe De-Escalating Aggressive Behaviour Scale: development and psychometric testing.\n\nAim.\n\nThis paper is a report of a study to develop and test the psychometric properties of a scale measuring nursing students’ performance in de-escalation of aggressive behaviour.\n\nBackground.\n\nSuccessful training should lead not merely to more knowledge and amended attitudes but also to improved performance.

However, the quality of de-escalation performance is difficult to assess.\n\nMethod.\n\nBased on SBE-β-CD chemical structure a qualitative investigation, seven topics pertaining to de-escalating behaviour were identified and the wording of items tested. The properties of the items and the scale were investigated quantitatively. A total of 1748 performance evaluations by students (rater group 1) from a skills laboratory were used to check distribution and conduct a factor analysis. Likewise, 456 completed evaluations by de-escalation experts (rater group 2) of videotaped performances at pre- and posttest were used to investigate internal consistency, interrater reliability, test-retest reliability, effect size and factor structure. Data were collected in 2007-2008 in German.\n\nFindings.\n\nFactor analysis showed a unidimensional

7-item scale with factor loadings ranging from 0 center dot 55 to 0 center dot 81 (rater group 1) and 0 center dot 48 to 0 center dot 88 (rater group 2). Cronbach’s LBH589 purchase alphas of 0 center dot 87 and 0 center dot 88 indicated good internal consistency irrespective of rater group. A Pearson’s r of 0 center dot 80 confirmed acceptable test-retest reliability, and interrater reliability Intraclass Correlation 3 ranging from 0 center dot 77 to 0 center dot 93 also showed acceptable results. The effect size r of 0 center dot 53 plus Cohen’s d of 1 center dot 25 indicates the capacity of the scale to detect changes in performance.\n\nConclusion.\n\nFurther research is needed to test the English version of the scale and its validity.”
“Freshwater mussel populations are declining in North America. Potential anthropogenic stressors may be contributing to the declines and may include the continual presence of pharmaceutical compounds in waterways. Diphenhydramine hydrochloride (DH) is an over-the-counter antihistamine marketed under several name brand products including the common U.S.

Among the total eight known compounds, reynoutrin and luteolin were isolated for the first time from the genus Psidium.”
“By a regular embedding of a graph K in a surface we mean a 2-cell embedding of K in a compact

connected surface such that the automorphism group acts regularly on flags. In this paper, we classify the nonorientable regular embeddings of the Hamming graph H(d, n). We show that there exists such an embedding if and only if n = 2 and d = 2, or n = 3 or 4 and d >= 1, or n = 6 and d = 1 or 2. We also give constructions and descriptions of these embeddings. (C) 2012 Elsevier Ltd. All rights reserved.”
“IntroductionMidwives GW-572016 in rural Ghana work at the frontline of the health care system, where they have access to essential data about the patient population. However, current methods of data capture, primarily pen and paper, make the data neither accessible nor usable for monitoring patient care or program evaluation. Electronic health (eHealth) systems present a potential mechanism for enhancing the roles of midwives by providing tools for collecting, exchanging, and viewing patient data as well as offering midwives the possibility for receiving information and decision

support. Introducing such technology in low-resource settings has been challenging because of low levels of user acceptance, software design that does not match selleck inhibitor the end-user environment, and/or unforeseen challenges such as irregular power availability. These challenges are often attributable to a lack of understanding

by the software developers of the end users’ needs and work LBH589 environment. MethodsA mobile health (mHealth) application known as mClinic was designed to support midwife access to the Millennium Village-Global Network, an eHealth delivery platform that captures data for managing patient care as well as program evaluation and monitoring, decision making, and management. We conducted a descriptive usability study composed of 3 phases to evaluate an mClinic prototype: 1) hybrid lab-live software evaluation of mClinic to identify usability issues; 2) completion of a usability questionnaire; and 3) interviews that included low-fidelity prototyping of new functionality proposed by midwives. ResultsThe heuristic evaluation identified usability problems related to 4 of 8 usability categories. Analysis of usability questionnaire data indicated that the midwives perceived mClinic as useful but were more neutral about the ease of use. Analysis of midwives’ reactions to low-fidelity prototypes during the interview process supported the applicability of mClinic to midwives’ work and identified the need for additional functionality. DiscussionUser acceptance is essential for the success of any mHealth implementation. Usability testing identified mClinic development flaws and needed software enhancements.”
“Anaplasma phagocytophilum, an obligate intracellular bacterium, modifies functions of its in vivo host, the neutrophil.