“
“Primary

objective: The purposes of this paper are to review: (1) the history of chronic traumatic encephalopathy (CTE) in sports, (2) the similarities and differences between historic and current definitions of CTE, (3) recent epidemiology and cohort studies of CTE and (4) controversies regarding the current CTE positions. Research design: see more Not applicable. Methods and procedures: Selective review of published articles relevant to CTE. Main outcome and results: The current definitions of CTE have evolved from its original definition and now rely heavily on the post-mortem detection of hyperphosphorylated tau for diagnosis. As of 2013, there is a blended cohort of 110 professional athletes diagnosed with CTE. It is being assumed that concussions and/or sub-concussive impacts in contact sports are the sole cause of CTE. Conclusions:

There are multiple causes of abnormal tau protein deposition in the human brain and the pathogenesis of CTE may not be related solely to concussion and/or sub-concussive injury. In all likelihood, the causes of CTE are a multivariate, as opposed to a univariate, phenomenon.”
“P>Low steady state haemoglobin oxygen saturation in MRT67307 patients with sickle cell anaemia has been associated with the degree of anaemia and haemolysis. How much pulmonary dysfunction contributes to low saturation is not clear. In a prospective study of children and adolescents with sickle cell disease aged 3-20 years at steady state and matched controls, 52% of 391 patients versus 24% of 63 controls had steady state oxygen saturation < 99% (P < 0 center dot 0001), 9% of patients versus no controls had saturation

< 95% (P = 0 center dot 008) and 8% of patients versus no controls had exercise-induced reduction in saturation >= 3%. Decreasing haemoglobin concentration (P < 0 center Galardin dot 001) and increasing haemolysis (P < 0 center dot 003) but not pulmonary function tests were independent predictors of both lower steady-state saturation and exercise-induced reduction in saturation. Neither history of stroke nor history of acute chest syndrome was significantly associated with lower steady-state oxygen saturation or exercise-induced reduction in saturation. Tricuspid regurgitation velocity was higher in patients with lower steady state haemoglobin oxygen saturation (P = 0 center dot 003) and with greater decline in oxygen saturation during the six-minute walk (P = 0 center dot 022). In conclusion, lower haemoglobin oxygen saturation is independently associated with increasing degrees of anaemia and haemolysis but not pulmonary function abnormalities among children and adolescents with sickle cell disease.”
“The membrane domain of human erythrocyte anion exchanger 1 (AE1) works as a C1(-)/HCO(3)(-) antiporter This exchange is a key step for CO(2)/O(2) circulation in the blood.