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“Introduction Fall incidents are the third cause of chronic disability in older persons according to the WHO [1]. One in three community-dwelling persons of 65 years and older Romidepsin supplier falls once per year [2–4] and about 25% of the fallers consult the general practitioner or Accidents and Emergency (A&E) department of a hospital [5, 6]. The consequences
may be severe and approximately 5% of the falls result in a fracture [6]. In older persons consulting the A&E Immune system department after a fall, the average total costs from the moment of the fall to 1 year later have been estimated at Euro 4,991 [7]. Because of the increasing number of older persons in the next decades, the number of fallers is expected to rise. Preventive measures are needed to reduce the number of falls and related costs. Although many trials have evaluated the effectiveness of preventive interventions, few have evaluated the cost-effectiveness of these interventions. Over the past decade, many randomised controlled trials (RCTs) have studied the effectiveness of multifactorial interventions, i.e. multifactorial evaluation and treatment of fall risk factors [8–16]. Despite conflicting results among original trials, meta-analyses seem to favour multifactorial interventions [17–19]. Although the evidence does not seem to be conclusive, international guidelines recommend multifactorial evaluation and tailored treatment of fall risk factors [20, 21]. Increasing numbers of geriatricians initiate fall prevention programs based on these guidelines. Given the large number of fallers, evaluation and treatment of every older person after a fall is not feasible.