We observed significant up-regulation of IGFBP-3 and Bax:Bcl-2 ratio and clown-regulation of cyclin-D1, p53, and Nrf-2 after cell incubation with sera from men who consumed
red tomato paste when compared with sera collected after the first washout period, with intermediate values for yellow tomato paste consumption. Cell incubation with sera from men who consumed purified lycopene led to significant up-regulation of IGFBP-3, c-fos, and uPAR compared with sera collected after placebo consumption.
Conclusion: Dietary Salubrinal datasheet lycopene can affect gene expression whether or not it is included in its food matrix. This trial was registered by the French Health Ministry at http://www.sante-sports.gouv.fr as 2006-A00396-45. Am J Clin Nutr 2010;91:1716-24.”
“Chemotherapy-induced peripheral neurotoxicity (CIPN) is one of the most severe and unpredictable side effects see more of modern anticancer treatment. In recent years, a clear understanding of the importance of an integrated approach to CIPN
has become evident, and efforts are increasing to better characterize its features and to identify more accurate methods to report and grade its occurrence. The clinically relevant impact of CIPN on cancer patients has been known for a long time, but knowledge of its pathogenetic aspects is still very limited. This incomplete knowledge is one of the major limitations in identifying targets for evidence-based neuroprotective strategies. Nevertheless, several studies have been devoted to the prevention or at least the effective treatment of symptoms secondary to peripheral nerve damage and to the early identification of patients at high risk of developing severe CIPN. Unfortunately, none of check details these studies has been successful and the optimal management of CIPN patients is still an unmet clinical need. Therefore, the modification of chemotherapy is currently the only available approach to limit the severity of neuropathy in the vast majority of
patients. The indications for treatment modification are not universally accepted and they can differ among the various drugs. Generally, treatment modification should be considered as soon as symptoms and signs impair the daily life activities of the patient, but the possibility of a delayed worsening of CIPN after treatment withdrawal (“”coasting”") should always be considered, and delay of modification decisions should be avoided.”
“Soluble oligomers of the amyloid-beta peptide (A beta Os) accumulate in Alzheimer’s disease (AD) brain and have been implicated in mechanisms of pathogenesis. The neurotoxicity of A beta Os appears to be, at least in part, due to dysregulation of glutamate signaling.