All other categorical variables are reported as raw frequencies. Saracatinib in vivo A multiple logistic regression was used to

estimate associations between “much or a little higher” perception of fracture risk and the seven individual FRAX risk factors; estimates for number of FRAX factors and osteoporosis diagnosis are from separate logistic regressions models. We did not adjust for age, as the outcome is perceived risk compared to women of the same age. Results Patient characteristics A total of 60,393 patients from practices of 723 physicians were enrolled in the study between October 2006 and February 2008. Approximately 25,000 women came from eight sites and 274 physician practices in Europe; 28,000 subjects were from 255 practices in the United States (US), and almost 7000 patients came from 86 practices in Canada and Australia. Among these women, 35% (20,345/58,434) rated their risk of fracturing or breaking a bone to be “much lower” or “a little lower” than that of women of the same age, 46% (27,138/58,434) said their risk was “about the same,” and 19% (10,951/58,434) rated their risk as “a little higher” or “much higher” than women of the same age (Table 1). Table 1 Perception of fracture risk compared with women of same age, by patient characteristic (n = 60,393) Group Perception of risk compared with women of same age (%) Much or a little lower

Nutlin-3a molecular weight (n = 20,345) About the same (n = 27,138) Much or a little higher (n = 10,951) All women 35 (20,345/58,434) 46 (27,138/58,434) 19 (10,951/58,434) Age group (years)  55 to 64 33 (7,374/22,632) 49 (11,192/22,632) 18 (4,066/22,632)  65 to 74 37 (7,574/20,672) 45 (9,377/20,672) 18 (3,721/20,672)  ≥75 36 (5,397/15,130) 43 (6,569/15,130) 21 (3,164/15,130) Regiona  Australia 37 (1,049/2,865) 46 (1,324/2,865) 17 (492/2,865) Pembrolizumab  Canada 33 (1,286/3,882)

48 (1,877/3,882) 19 (719/3,882)  Northern Europeb 33 (4,427/13,334) 53 (7,014/13,334) 14 (1,893/13,334) (26–47) (38–61) (13–15) (706/2,715–1,556/3,298) (1,244/3,298–1,678/2,715) (331/2,715–498/3,298)  Southern Europec 31 (3,359/10,887) 49 (5,308/10,887) 20 (2,220/10,887) (19–37) (45–53) (15–28) (518/2,828–1,227/3,320) (1,432/3,135–1,538/2,828) (509/3,320–772/2,828)  USA 37 (10,224/27,466) 42 (11,615/27,466) 20 (5,627/27,466) (33–43) (39–44) (15–23) (1,359/4,145–1,704/3,969) (1,180/3,066–1,832/4,145) (590/3,969–717/3,074) aAge standardized to the GLOW population; range of regional site rates in brackets bBelgium, Germany, The Netherlands, United Kingdom cFrance, Italy, Spain Subgroup analyses When perceptions were viewed by age, the distributions were similar for the three age groups (Table 1), with a slightly greater proportion (21%, 3,164/10,951) of women 75 years and older considering themselves to be at higher risk for fracture.