This article chronicles the development of the Department of Neurological Surgery at the University of Wisconsin, directed by its 3 chairmen, in the context of the University, the state of Wisconsin, and the Midwestern United States.”
“Three-dimensional (3D) type I collagen gels are increasingly utilized to simulate extracellular matrix (ECM) in vivo, but little is known about the effects of age on this model. Collagen was extracted from
young (4-6 months) and aged (20-24 months) mice tails and compared. The collagens appeared similar by electrophoresis. However, relative to young, aged collagen formed fibrils slower and generated 3D gels with smaller diameter, less dense fibrils (75 vs 34 nm diameter and 8 vs 3.5% area, for young and aged respectively, p < 0.02). Correspondingly, aged collagen gels were more malleable and contractible (5% vs 19%
compression, p < .02, and 73% vs 15.5% area, p < .01. for young and aged, respectively). GSK923295 concentration Fibroblasts cultured within young and aged collagen gels had GSK J4 solubility dmso differential expression of a limited number of genes and proteins corresponding to specific integrins and matrix components. In summary, collagen extracted from young and aged mice is an effective means to examine the influence of aging on functional properties of ECM that are relevant in vivo.”
“ESMAIL JORJANI WAS a prominent Persian physician of the 11th and 12th centuries. We present Jorjani’s descriptions of probable trigeminal neuralgia, hemifacial spasm, and Bell’s palsy. Additionally, on the basis of our translations of his original text, we believe that Jorjani may have been the first to implicate an artery-nerve conflict as an etiology of trigeminal neuralgia. This theory, documented in Jorjani’s Treasure of the Khawarazm Shah and elaborated on by Dandy and Jannetta, constitutes the basis of a modern surgical approach to trigeminal neuralgia. The authors also describe the life and works of Esmail Jorjani and review his Treasure for its descriptions
related to the aforementioned cranial nerve Dolichyl-phosphate-mannose-protein mannosyltransferase pathologies.”
“The lysosomal protease cathepsin D is likely involved in beta-amyloidogenesis in Alzheimer’s disease (AD). There is evidence for a single nucleotide polymorphism (rs17571) of the cathepsin D gene to be associated with increased AD risk. However. little is known about gender-specific differences. Therefore, we performed a genetic association study focusing on gender-specific differences in 434 participants (219 AD and 215 controls). Screening of the rs17571 shows a significantly higher proportion of T-allele carriers among male Alzheimer patients (28.5%) when compared with male controls (13.8%. p = .013. p(co pi) = .039). The odds ratio was 2.48 (95% confidence interval: 1.14-5.58). There was no significant difference in the T-allele distribution in women. Including APOE4 status and age did not have an additional effect on the morbidity risk.