The results provide new insight into the pathogenesis of GIST and suggest an efficacious therapy for GIST. Terminology GISTs are low-grade malignant mesenchymal tumors of the gastrointestinal tract and are believed to originate from neoplastic transformation of the interstitial cells of Cajal. Antisense therefore oligodeoxyribonucleotides are short DNA sequences that do not form hybrids with noncomplementary RNAs encoded by other genes, and thus each individual oligodeoxyribonucleotide targets a unique RNA sequence, thereby effectively blocking the expression of the associated gene while transcription from other genes remains unaffected. Peer review The authors of this study investigated the pathogenesis of GISTs. The results are interesting and suggest that telomerase activity was repressed and the level of bcl-2 mRNA significantly downregulated in SCID mice treated with PS-ASODN.
They investigated the effect of PS-ASODN on proliferation, apoptosis, and telomerase activity of tumor cells in mouse transplanted GISTs, with the goal of attaining a new viewpoint on GIST pathogenesis and providing a new therapeutic intervention. Footnotes Supported by The Natural Science Foundation of Zhejiang Province, No. Y201016273 P- Reviewers Andrei S, Kanda T S- Editor Zhai HH L- Editor Logan S E- Editor Li JY
Oesophageal cancer, and in particular, oesophageal adenocarcinoma, has seen an unprecedented rise in incidence during recent years (Devesa et al., 1998). Five-year survival is less than 8% as the majority of patients have advanced, unresectable disease upon presentation (CRUK, 2012).
The current standard of care is pre-operative chemotherapy followed by surgery in patients with locally advanced resectable disease and palliative chemotherapy for unresectable disease. However, response rate to standard chemotherapy regimens is poor (Gr��nberger et al., 2007; Courrech Staal et al., 2010). While Barrett’s metaplasia is the major risk factor for the development of oesophageal adenocarcinoma, lifestyle factors, including obesity and diet, are also important (Lagergren, 2005). In particular, emerging evidence suggests that dietary iron is associated with oesophageal carcinogenesis (Haggitt, 1994; Ward et al., 2012). This association is supported by animal models demonstrating that increasing body iron can markedly amplify tumourigenesis (Hann et al., 1988; Chen et al., 1999; Chen et al., 2000; Pierre et al., 2003; Ilsley et al., 2004; Seril et al., 2005). In the context of oesophageal tumourigenesis, Chen et al. (1999; Brefeldin_A 2000) showed that rates of oesophageal adenocarcinoma were 10-fold higher in rodents subjected to i.p. injections of iron dextran compared with untreated controls.