Results: Statistically significant correlations between radiographic severity and the overall magnitude of the knee adduction moment during stance (r(2)

= 21.4%, P = 0.003) and the magnitude of the knee flexion angle during the gait cycle (r(2) = 11.4%, P = 0.03) were found. Significant correlations between pain and gait speed (r(2) = 28.2%, P < 0.0001), the activation patterns of the lateral gastrocnemius (r(2) = 16.6%, P = 0.009) and the medial hamstring (r(2) = 10.3%, P = 0.04) during gait were found. The combination of the magnitude of the knee adduction moment during stance and BMI explained a significant portion of the variability in radiographic severity (R-2 = 27.1%, P < 0.0001). No multivariate model explained pain severity better than gait speed alone.

Conclusions: This study suggests that some knee joint

biomechanical AZD2171 datasheet learn more variables are associated with structural knee OA severity measured from radiographs in clinically diagnosed mild to moderate levels of disease, but that pain severity is only reflected in gait speed and neuromuscular activation patterns. A combination of the knee adduction moment and BMI better explained structural knee OA severity than any individual factor alone. (C) 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.”
“Background: The rupture of intracranial aneurysms leads to subarachnoid hemorrhage, which is often associated with poor outcome. Preventive treatment of unruptured intracranial aneurysms is possible and recommended. However, the lack of candidate genes precludes identifying patients at risk Selleckchem EPZ5676 by genetic analyses.

We observed intracranial aneurysms in 2 patients with von Hippel-Lindau (VHL) disease and the known disease-causing mutation c.292T > C (p.Tyr98His) in the VHL tumor suppressor gene. This study investigates whether the VHL gene is a possible candidate gene for aneurysm formation. Methods: Patients with intracranial aneurysms admitted to our department between 2006 and 2009 were enrolled. The peripheral leukocyte DNA of 200 patients was investigated for sequence variations in the VHL gene using denaturing high performance liquid chromatography. Peripheral leukocyte DNA of 100 randomly sampled probands was investigated as a control group. The allelic frequencies of sequence variations between both groups were compared using the Fisher exact test. Results: Fourteen of 200 patients with intracranial aneurysms had sequence variations at 6 different loci in the VHL gene. In contrast, no sequence variations were identified in 100 probands in the control group (P = 0.0062). However, none of the single-sequence variations had a statistically significant difference in the allelic frequencies compared to the control group. Conclusions: There is accumulating evidence for a genetic basis of aneurysm development.