Results SFTSV- RNA of all the 22 patients was positive. SFTSV load 1×107 (copies / ml) in 4 patients, 2 cases died; In the early stage of SFTSV-infection, serum ALT/AST/LDH/CK markedly elevated and WBC and PLT in peripheral blood decreased significantly. The level of ALT/AST/LDH/CK, WBC and PLT in 19 cured patients was gradually backed to normal with the reducing of viral load. The elevated level of serum AST/LDH/CK and SFTSV load positively correlated, PLT and SFTSV load negatively

correlated. At the same stage of infection process, ALT/AST/LDH/CK in incurable patients were significantly higher than in cured Rapamycin price patients; Compared with healthy population, the number of CD4+ cells was lower in the onset of the first 5 to 9 days; CD8+ cells was higher and NK cells was lower HDAC phosphorylation in 9 to 15 days. Lymphocyte subsets of most patients were normal with the viral load undetectable; The number of T cells of incurable patients significantly decreased, while NK cells increased. A variety of detection indicators could not recover with extension of disease course. Conclusion Liver may

be one of the target organs of SFTSV-infection injuries. Severity of tissue damage is closely related to serum SFTSV load. High viral load, decreasing of T cells, increasing of NK cells may be the important factors of poor prognosis. Disclosures: The following people have nothing to disclose: Jun Li, Yaping Han, Longfeng Jiang, Zuhu Huang Background: Conventional resuscitation (CR) from hemorrhagic shock (HS) that restores

central hemodynamic function nonetheless Etomidate results in gut and liver hypoperfusion and hypoxia, organ and cellular edema, and liver injury. This can lead to multi-system organ failure and death. Minocycline stabilizes mitochondrial membrane function inhibiting mitochondrial transition pore opening and cytochrome C release-mediated apoptosis. We hypothesized that minocycline might improve post-resuscitation (post-RES) hepatic function and, thus, prevent hepatic injury following hemorrhagic shock. Methods: Anesthetized male Sprague-Dawley rats were randomized to groups (n=7/group): 1) Sham (no HS); 2) Sham + Minocycline at time of RES (Sham + Min(0″)); 3) Sham + Min at 120″ min post-RES (Min(120″)); 4) HS + CR; 5) HS + CR + Min(0″); and 6) HS + CR + Min(120″). At 4 hours post-RES, we measured: 1) effective hepatic blood flow (EHBF) by galactose clearance; 2) hepatic injury (serum ALT); 3) CMP & CBC; 4) tissue edema (lung, liver, or ileum wet-dry weight ratios); and 5) lung, liver, and ileum histopathology. Results: Histopathology showed lung and liver injury in HS + CR at 4 hours post-RES. Serum ALT levels were increased in HS+CR but not in HS + CR + Min(0″) or HS + CR + Min(120″). During HS, all HS + CR groups had decreased EHBF that was restored by i.v. blood and saline RES.