Results: Of 105 patients with donor search, 97 (matches 83; controls 14) were
assessable NU7441 mw at the 3-month landmark. Matches and controls were comparable for age, gender, time from diagnosis, number of previous regimens, and remission status. Disregarding if alloSCT was actually carried out or not, survival from the 3-month landmark was significantly better in matches versus controls [hazard ratio 0.38, 95% confidence interval (CI) 0.17-0.85; P = 0.014]. The survival benefit of matches remained significant on multivariate analysis. Conclusion: This study provides first comparative evidence that alloSCT may have the potential to improve the natural course of poor-risk CLL as defined by the EBMT criteria.”
“PURPOSE: To evaluate the efficacy and safety of prompt intravitreal triamcinolone acetonide injection (4 mg/0.1 mL) vs intravitreal bevacizumab injection (1.25 mg/0.05 mL) compared with observation in the management of extensive exudative retinal detachment secondary
to posterior uveal melanoma.\n\nDESIGN: Retrospective, nonrandomized, interventional case series.\n\nMETHODS: SETTING: Institutional. PATIENTS: Ninety-six patients affected by posterior uveal melanoma with large exudative retinal detachment (>10 mm in largest basal diameter) were included. INTERVENTION: Patients received intravitreal triamcinolone acetonide (32 eyes) or intravitreal GDC-0941 in vitro bevacizumab (32 eyes) at plaque removal. Thirty-two patients served as controls GSK2879552 Epigenetics inhibitor (observation group). All groups were matched for age, sex, initial tumor thickness and largest basal diameter, largest exudative retinal detachment basal diameter, tumor location, and Bruch membrane rupture. Patients underwent monthly follow-up examinations in the first 6 months and every 3 months thereafter. Follow-up was longer than 24 months. MAIN OUTCOME
MEASURE: Exudative retinal detachment resolution (B-scan ultrasonography), steroid-induced cataract, steroid-induced increased IOP.\n\nRESULTS: Follow-up was 37 +/- 7 months. Marked exudative retinal detachment regression was documented in 22 (69%) intravitreal triamcinolone acetonide treated vs 11 (34%) intravitreal bevacizumab treated and 9 (28%) untreated eyes (P = .0007 and P = .0001, respectively). No statistical significance was found between intravitreal bevacizumab group vs observation group (P = .45) Steroid-induced cataract was observed in 4 intravitreal triamcinolone acetonide treated patients (12%). Neither steroid-induced increased IOP nor other short- or long-term side effects were documented.\n\nCONCLUSION: Intraoperative intravitreal triamcinolone acetonide injection induces earlier and marked exudative retinal detachment resolution after brachytherapy of posterior uveal melanoma. Risk and benefit should be balanced vs steroid-induced cataract. (Am J Ophthalmol 2013;155:127-133. (C) 2013 by Elsevier Inc. All rights reserved.