Pyrano[2,3-b] indol-2(9H)-ones are synthesized by three different metal-free syntheses (DCC, DMSO; CDI, DBU, CH2Cl2; or Mukaiyama’s KU-55933 mouse reagent, Et3N, MeCN) and pyrano[2,3-b]indol-4(9H)-ones are prepared by one-pot or two-step synthesis. Pyrazolo[3,4-b]indoles are synthesized by Fischer indole type cyclization and McMurry coupling is employed for

the synthesis of furo[2,3-b]indoles. All these core structures are synthesized from simple, common 3-acetylindol-2-ols.”
“Four indigenous thermo-tolerant Desmodesmus sp. strains were examined for their ability to produce lutein. Among them, Desmodesmus sp. F51 was the best strain for this purpose. The medium composition, nitrate concentration and light intensity were manipulated to improve the phototrophic growth and lutein production of Desmodesmus sp. F51. It was found that a nitrogen-sufficient condition was required for lutein accumulation, while a high light intensity enhanced cell growth but caused a decrease in the lutein content. The best cell growth and lutein production occurred when the light intensity and initial nitrate concentration were 600 mu mol/m(2)/s and 8.8 mM, respectively. The fed-batch cultivation strategy was shown to further improve lutein production. The highest lutein productivity (3.56 +/- 0.10 mg/L/d) and content

(5.05 +/- 0.20 mg/g) were obtained when pulse-feeding of 2.2 mM nitrate was employed. This study demonstrated the potential of using Desmodesmus sp. F51 as a lutein producer in practical Fer-1 clinical trial applications. (C) 2013 Elsevier Ltd. All rights reserved.”
“Background. The submandibular gland is commonly removed during neck dissection involving sublevel IB. However, removal reduces basal salivary secretion and therapeutic options for minimizing xerostomia. The purpose of this study was to determine whether all lymph nodes in sublevel IB can be extirpated without removing the submandibular gland.\n\nMethods.

Twenty consecutive patients undergoing 33 neck dissections were prospectively enrolled. Sublevel IB dissection was performed by 3 sequential steps: (1) removal of targeted lymph node groups (preglandular and postglandular, prevascular and postvascular), (2) removal of submandibular gland, and (3) removal of residual lymphoadipose tissue in the surgical bed.\n\nResults. Complete removal of lymph nodes in sublevel IB Selleckchem A-1210477 was achieved before excising the submandibular gland in all of the 30 eligible neck dissections. The submandibular gland and the surgical bed contained no residual lymph nodes.\n\nConclusion. In suitable cases, it is technically feasible to remove all lymph nodes in sublevel IB and preserve the submandibular gland. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 603-609, 2011″
“BACKGROUND: Up to now the effect of inhibitory compounds on the anaerobic digestion performance of urban and industrial wastewaters has been mostly studied in fluidized bed and upflowing anaerobic sludge blanket (UASB) bioreactors but not in upflow packed-bed biodigesters.