Patients currently participating in other smoking cessation programs were also deemed ineligible. kinase inhibitor JQ1 Study Design and Procedures After the informed consent process, participants were asked to complete an audio computer-assisted self-interview (ACASI) consisting of sociodemographic, smoking-related, health behavior, and psychosocial variables. Following this assessment, all participants received brief advice to quit smoking from a health care provider, self-help written materials, and instructions on how to obtain nicotine replacement therapy (NRT) patches at TSHC. These treatment elements were delivered in accordance with the Public Health Services guidelines (Fiore et al., 2008). Participants were then randomized into either a UC or a CPI treatment group.

Adaptive randomization was used to ensure treatment group balance with respect to several important participant characteristics (i.e., depression history, number of cigarettes per day, and nicotine dependence; Friedman, Furberg, & DeMets, 1998; Taves, 1974). Participants were given $20 gift cards as compensation for completing the baseline assessment. Participants randomized to UC received no further treatment, while participants randomized to the CPI group were given a prepaid cell phone on which a series of 11 proactive counseling sessions were conducted. The phone calls spanned a 3-month period but were front loaded such that the frequency of the calls was highest near the time of scheduled quit attempt. Counseling session content was primarily drawn from a cognitive�Cbehavioral foundation.

Problem solving and skills training techniques, which are empirically supported for smoking cessation, were emphasized (Fiore et al., 2008). Participants in the CPI group were also given access to a hotline to call if additional support was sought between sessions. Participants were allowed to keep the cell phones following the completion of the 3-month treatment period. See Table 1 for the call schedule, a description of the counseling session content for each call and the proportion of calls successfully completed. Table 1. Cell Phone Intervention: Timing, Content, and Completion Rate of the Proactive Phone Counseling Sessions All participants were asked to complete a follow-up assessment approximately 3 months post-study enrollment. The format of the follow-up closely mirrored the format of the baseline assessment.

That is, follow-ups were conducted at the time of routinely scheduled primary care clinic appointments, and an ACASI approach was used. Expired CO level was also measured to biochemically verify smoking status. Participants Cilengitide completing the 3-month follow-up were given another $20 gift card. Preliminary findings from this RCT are limited to outcomes collected at the 3-month assessment. However, participants were also asked to complete 6-month and 12-month assessments in this ongoing trial.