MRI will deliver more detailed site-specific volumetric measures, but will require substantial further processing post-acquisition. UK Quisinostat research buy Biobank access procedures are documented on the website (www.ukbiobank.ac.uk); fees are modest and reflect only the need for recovery of costs associated selleck inhibitor with data
processing and provision. A short initial application is required, followed by a more detailed full application, and then a material transfer agreement. Any additional assays, subject to sample availability, are at the expense of the applicant, and the results fed back into the central dataset so that they are available for subsequent researchers. There is currently a great potential for cross-sectional investigations based on prevalent disease. As cases of incident disease accrue, and the Imaging Enhancement is completed, there will be enormous possibilities for the international musculoskeletal community to undertake uniquely powered ground breaking studies, both within bone and joint, and linking with other
organ systems, to comprehensively investigate the determinants of later disease. Acknowledgments The authors would like to thank the Imaging Working Group for their expertise: Chair: Prof. Paul Matthews (Brain MRI; London); Prof. Jimmy Bell (Body MRI; London); selleckchem Prof. Andrew Blamire (MR physics; Newcastle); Prof. Sir Rory Collins (Epidemiology; UK Biobank/Oxford); Dr. Paul Downey (Feasibility; UK Biobank); Dr. Tony Goldstone (Body MRI; London); Dr. Nicholas Harvey (Bone/joint/body DXA; Southampton); Dr. Paul Leeson (Carotid ultrasound; Oxford); Dr. Karla Miller (MR physics; Oxford); Prof. Stefan Neubauer (Cardiac MRI; Oxford); Dr. Tim Peakman
(Feasibility; UK Biobank); Dr. Steffen Petersen (Cardiac MRI; London); Prof. Stephen Smith (Brain MRI; Oxford); Secretariat: Ms Nicola Doherty and Ms Kirsty Lomas (UK Biobank) Conflicts of interest NH is Lead for DXA Assessment on the UK Biobank Imaging Working Group and a co-author of the UK Biobank Imaging Enhancement proposal. PM is Chair of the UK Biobank Imaging Working Group and oversaw the Imaging Enhancement proposal. He is a part-time employee of GlaxoSmithKline Research and Development, Ltd. and receives Nintedanib (BIBF 1120) research funding from the MRC. RC is Principal Investigator and Chief Executive of UK Biobank, and a member of the Imaging Working Group. CC is a co-author UK Biobank Imaging Enhancement proposal. References 1. Collins R (2012) What makes UK Biobank special? Lancet 379:1173–1174PubMedCrossRef 2. WHO (2010) Global status report on noncommunicable diseases. World Health Organization, Geneva 3. Elliott P, Peakman TC (2008) The UK Biobank sample handling and storage protocol for the collection, processing and archiving of human blood and urine. Int J Epidemiol 37:234–244 4.