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al.: Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney. Cancer Res 2009, 69: 4674–4681.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions KB performed the database interrogation Megestrol Acetate and the SOSTDC1 LOH analysis and sequencing. KC carried out the sample staining and manuscript preparation. GH oversaw the SOSTDC1 LOH analysis and sequencing. AG assisted with the Wilms tumor tissue procurement. MW provided technical advice and interpretations for the immunohistochemistry results. JT aided in the SOSTDC1 LOH analysis and sequencing. FT assisted with the experimental design and interpretation. ST oversaw experiment planning, interpretation, and manuscript preparation. The final manuscript was read and approved by all authors.”
“Background Hepatoma is the sixth most common cancer worldwide. Its incidence increased rapidly and becomes the leading cause of cancer-related deaths in the world[1]. To date, chemotherapy has been the most frequently used treatment for liver cancer and other cancers. However, The toxicity of these chemotherapy medicines to normal tissues and normal cells has been one of the major obstacles to successful cancer chemotherapy. Obviously, there is an urgent need to identify new therapeutic agents for the treatment of hepatoma.