Finally, while some patients in our sample were on stable doses of antipsychotic drugs (which were not included in the analyses as covariates of no interest), the high interindividual variability with respect to treatment histories, procedures, and responses should be considered as a general limitation in this kind of research. Specifically, several studies demonstrated a significant improvement

in cognitive performance secondary to dopaminergic effects of selective serotonin reuptake inhibitors Inhibitors,research,lifescience,medical (Borkowska et al. 2002), while anxiolytic effects of benzodiazepines might also contribute to an improved performance in highly anxious patients (Desai et al. 1983). The fact that we observed in our medicated sample persistent neuropsychological deficits despite symptom control,

would suggest that such impairments are stable trait-like features of OCD (Bannon et al. 2006). On the other hand, few available pieces of evidence confirm that psychotropic drugs can affect WM microstructure (Yoo et al. 2007), and the FA changes observed in our OCD Inhibitors,research,lifescience,medical patients might not necessarily Inhibitors,research,lifescience,medical be an index of WM pathology, but could reflect a yet unexplored part of the mechanism of action of drugs used in psychiatric treatment, or be a marker of the biological effect of psychotropic drugs on the brain (Benedetti et al. 2013). Nevertheless, this perspective is highly speculative because existing animal models have well-correlated DTI measures with WM lesions, and future studies examining WM integrity before and after treatment will Inhibitors,research,lifescience,medical contribute to clarify this issue. Conflict of Interest None declared. Funding Information This work was supported by the Italian Ministry of Health (Grant numbers RC 06-07-08-09-10, RF 06-07-08).
The effects of physical sensations on overt behavior have been subject to extensive research, often based on the somatic marker hypothesis (SMH, Damasio et al. 1991; Bechara et al. 1994; Damasio 1995). The SMH suggests, for example, that somatic cues guide decision making in complex situations, which are characterized by little Inhibitors,research,lifescience,medical explicit information to base a decision on, and/or time

pressure. More specifically, the SMH posits, that responses in such situations are ERK signaling pathway inhibitor associated with specific, learned somatic states (e.g., heart rate, skin conductance, muscle tone), which were previously evoked by similar decisions. These “emotional marker” signals are represented Org 27569 in the anterior insular cortex and embedded in decision-making processes via ventromedial prefrontal pathways (Damasio 1995). An established paradigm for the assessment of intuitive decision-making patterns under time pressure and with incomplete information is the Iowa Gambling Task (IGT, Bechara et al. 1994). Implicit learning skills have been reported to be positively associated with IGT performance (Bechara et al. 1997). The main body of literature has considered skin conductance response as a proxy for visceral somatic markers (Dunn et al.