6% to 98.1%. On the other hand, the resistance to anthelmintic drugs becomes a serious problem in countries with small ruminants industry (Thomaz-Soccol

et al., 2004 and Vieira et al., 1992). In present study, there was not an EPG decrease in the Moxidectin 0.2% group, even being given every 30 days. In sheep raised in Brazil, H. contortus is the main parasite involved in cases of Moxidectin resistance ( Thomaz-Soccol et al., 2004 and Silva et al., 2008). These results are consistent to the previously reported, with a possible resistance to moxidectin. However, the authors suggest the association of biological control with chemical control, which could help in reducing of helminth infections. In the coprocultures, there was a predominance of Strongyloides sp. in the first quarter, probably due to the goats being young, with a mean age of 8 months, being more susceptible to infection by this gender. In the second quarter, there was selleck compound the predominance of Haemonchus sp., corroborating with Araújo et al. (2007), who observed a greater percentage of this gender in goat feces in a semi-arid region of Ceará, Brazil. Due to the high rainfall in April and May, there was a rise in

the EPG caused by the humidity’s increase, which contributed to a higher re-infection in animals. In the same period, there was a decrease in the PCV. Therefore, all animals in the Control group and five animals in the Moxidectin 0.2% group required salvage de-worming during this period. D. flagrans was able to prevent Crizotinib supplier re-infection, where only one animal required salvage de-worming.

It was observed that the D. flagrans group increased 65% in weight, the Moxidectin 0.2% group increased 38% and the Control group had a 9% of reduction in weight. Chandrawathani et al. (2004) observed that the sheep greater weight Mannose-binding protein-associated serine protease gain in Malaysia occurred in the group receiving. D. flagrans. On the other hand, Silva et al. (2009) found no statistical difference (p > 0.05) in the weight of D. flagrans group and the Control group. The PCV of D. flagrans group were higher than the other groups throughout the experiment, demonstrating that this group had a better physiological response against gastrointestinal parasitism. These results disagree with Silva et al. (2010), who observed that the PCV of sheep receiving D. flagrans was slightly lower than the other groups. In the leukocyte counts, changes were observed due to the occurrence of bacterial diseases of respiratory origin which affected all the animals in the experiment, explaining chronic leukocytosis with neutrophilia. The animals were affected mainly in April and May, the rainy season, where the relative humidity was high. To avoid possible interference in the anthelmintic treatment, no antibiotic treatments were performed, explaining the persistence of changes in the exams until the month of July, when the rainfall and relative humidity had already decreased, allowing the animals to overcome the infection. D.