2). 3.1.3 10-mg Tablets The Prolanz FAST® formulation has a quick Rabusertib concentration dissolution time, but shows a longer delay to catch up to the Zydis® formulation, taking 2 min before they are equivalent (data not shown; see Figs. 1, 2 for 5-mg dose profiles). At a lower agitation rate of 20 rpm, olanzapine Zydis® 10 mg still has the fastest dissolution rate in the first 3 min, and olanzapine Zydis® dissolution is not significantly affected by dosage strengths (5, 10 mg). However, the Prolanz FAST® dissolution rate is affected by the increased mass of the tablet. 3.1.4 15-mg Tablets At 20 min, the VX-770 chemical structure generic ODTs released less than 60 % of active compound, while olanzapine Zydis® released

95 %. At the 90-min time point, and with increased agitation, the generic ODTs reached 96–112 % release. 3.1.5 20-mg

Tablets The olanzapine Zydis® ODT formulation is the fastest to disintegrate and dissolve. With a longer dissolution time (90 min) and increased agitation, all products were close to 100 % released at the final time point. The freeze dried ODT dissolution profiles are very similar regardless of the tablet mass or active ingredient content. Generic ODT formulations using conventional compression or molding methods of manufacture were significantly slower to dissolve as the mass of the tablet increased. 4 Discussion Based on our results, we found potentially important differences between ODT formulations manufactured with different SRT2104 in vivo technologies. The simulated saliva in vitro dissolution test may be considered a proxy for the disintegration process in a patient’s mouth because it mimics

the oral cavity environment and solutions. Differences in ODT formulation, manufacturing process, and tablet mass are associated with different disintegration times, which may have a potential impact on their use in clinical nearly practice. Different disintegration times and tablet residue could influence mouth feel and the ability to swallow unaided by fluids, which could, in turn, influence adherence to treatment. It is important to note that several generic tablet disintegration rates are slow enough to permit ‘cheeking’ and expectoration of the medication. Surreptitious rejection of medication by patients occurs sometimes in clinical practice [15]. If a tablet is swallowed and the pH becomes more acidic, the olanzapine will dissolve more rapidly than in the more neutral pH of saliva; however, the time for complete disintegration may be no better than in the mouth. Clinicians need to be aware of the potential differences among products, because it could differentially influence the success of this behavior. The use of polymeric excipients, which swell in water to speed disintegration, may inhibit rapid and complete dissolution of the active ingredient in some formulations.