2-4-[4-(2-Fluorophenyl)piperazin-1-yl]butyl-4,10-diphenyl-1H,2H,3H,5H-indeno[1,2-f]isoindole-1,3,5-trione

(15) Yield: 88 %, m.p. 245–247 °C. 1H NMR (DMSO-d 6) δ (ppm): 7.61 (t, 3H, CHarom., J = 3.9 Hz), 7.56–7.44 GDC-0068 manufacturer (m, 8H, CHarom.), 7.41–7.30 (m, 2H, CHarom.), 7.21–7.00 (m, 4H, CHarom.), 6.23 (d, 1H, CHarom., J = 7.8 Hz), 3.50–3.37 (m, 8H, CH2), 3.21–3.08 (m, 4H, CH2), 1.70–1.68 (m, 2H, CH2), 1.58–1.53 (m, 2H, CH2). 13C NMR (CDCl3) δ (ppm): 191.47, 166.12, 165.97, 149.48, 148.57, 141.72, 137.16, 135.69, 134.38, 134.21, 134.09, 133.92, 132.46, 130.85 (2C), 129.36 (2C), 129.29 (3C), 128.63 (2C), 128.52 (3C), 128.47 (2C), 127.69 (4C), 124.82, 123.96, 57.06, 56.93, 50.46, 50.27, 36.12, 34.98, 29.58, 26.02. ESI MS: m/z = 636.4 [M+H]+ (100 %). 2-4-[4-(4-Fluorophenyl)piperazin-1-yl]butyl-4,10-diphenyl-1H,2H,3H,5H-indeno[1,2-f]isoindole-1,3,5-trione (16) Yield: 93 %, m.p. 241–242 °C. 1H NMR (DMSO-d 6) δ (ppm): 7.61 (t, 3H, CHarom., J = 3.9 Hz),

7.56–7.53 (m, 1H, CHarom.), 7.51–7.48 (m, 3H, CHarom.), 7.47–7.46 (m, 5H, CHarom.), 7.41–7.30 (m, 2H, CHarom.), 7.13–7.07 (m, 2H, CHarom.), 7.03–6.98 (m, 2H, CHarom.), 3.67 (d, 2H, CH2, J = 9.0 Hz), Evofosfamide datasheet 3.47–3.42 (m, 4H, CH2), 3.06 (d, 6H, CH2, J = 8.4 Hz), 1.69–1.68 (m, 2H, CH2), 1.57–1.54 (m, 2H, CH2). 13C NMR (CDCl3) δ (ppm): 191.19, 166.58,

165.74, 149.53, 148.82, 141.13, 137.64, 135.97, 134.27, 134.09, 134.01, 133.84, 132.16, 130.76 (2C), 129.94 (3C), 129.59 (2C), 128.89 (3C), 128.72 (3C), 128.11 (2C), 127.75 (3C), 125.49, 123.52, 57.68, 57.51, 50.94, 50.00, 36.81, 34.86, 29.37, 26.97. ESI MS: m/z = 636.4 [M+H]+ (100 %). 2-4-[4-(4-Chlorophenyl)piperazin-1-yl]butyl-4,10-diphenyl-1H,2H,3H,5H-indeno[1,2-f]isoindole-1,3,5-trione (17) Yield: 82 %, m.p. 1H NMR (DMSO-d 6) δ (ppm): 7.61 (t, 3H, CHarom., J = 3.6 Hz), 7.56–7.53 Docetaxel in vivo (m, 1H, CHarom.), 7.51–7.48 (m, 2H, CHarom.), 7.47–7.45 (m, 5H, CHarom.), 7.40–7.30 (m, 2H, CHarom.), 7.31–7.27 (m, 2H, CHarom.), 7.00 (d, 2H, CHarom., J = 9.0 Hz), 6.23 (d, 1H, CHarom., J = 7.5 Hz), 3.77 (d, 2H, CH2, J = 10.8 Hz), 3.49–3.72 (m, 4H, CH2), 3.07–3.01 (m, 6H, CH2), 1.68–1.66 (m, 2H, CH2), 1.57–1.52 (m, 2H, CH2).