1 for femoral neck BMD [20]. Data from the present study revealed that women with prevalent vertebral fractures had significantly lower BMD ISRIB ic50 than those without prevalent vertebral fractures. The odds of having a prevalent vertebral

fracture per SD reduction in BMD at the spine and hip after adjustment for age was 1.5 This findings are similar to the US white (OR = 1.8) and black women (OR = 1.5–1.6) [23]. Furthermore, the ability in discriminating prevalence vertebral fracture using BMD at the spine and hip in Southern Chinese women is similar to that of other ethnic groups (AUC = 0.627 and 0.612 in Southern Chinese, 0.660 and 0.672 in US white, and 0.660 and 0.655 in US black women at the spine and femoral neck respectively) [23]. Likewise, the published Study of Women’s Health Across the Nation (SWAN) have demonstrated that BMD was comparable between Asian and Caucasian women after adjustment for body click here size [31]; therefore, the similarity in the prevalence of vertebral fracture in Southern Chinese and other ethnic groups seems possible. It has been thought that BMAD would provide a more accurate estimate of volumetric BMD

because BMAD would compensate for ethnic differences in bone size. However, our results have demonstrated that BMAD did not improve vertebral fracture risk prediction when compared with BMD. The findings suggest that it is not necessary to use BMAD clinically for fracture risk prediction. Despite the similarities in the discriminating power between the Southern Chinese model and the US white and black models using BMD as a discriminator, the clinical

selleck compound risk factors identified were different between the populations, suggesting the importance of population characteristics and lifestyle factors in the pathogenesis of osteoporotic fractures. Interestingly, evaluation of clinical risk factors revealed that the addition of BMD to other factors did not improve the discriminative ability in identifying subjects with vertebral fractures. This observation suggested that clinical risk factors such as age, BMI, menarche age, past history of fracture, and falls are significant contributors to osteoporotic fracture risk over that provided by BMD. The findings are in agreement with previous reports of the World Health Organization algorithms (FRAX®) for the 10-year absolute risk prediction [32–34]; we found that the prevalence of vertebral fracture was similar between those with or without the addition of BMD T-score to the model. In view of the limited and variable access to radiology investigations in most health care systems in the world, a simple management scheme using clinical risk factors to identify patients for further evaluation would be a more practical approach in the management of osteoporosis. The present study has several 3-Methyladenine supplier strengths. First, a community-based population was used to investigate the prevalence of radiographic vertebral fractures.