Previous studies have treated special clinical and histopathological Axitinib supplier types of BCC mostly on the trunk by CO2 laser, but we treated various clinical (nodular, superficial, and pigmented) and histopathological types of BCC on the periorbital area that involved eyelash line by superpulsed

CO2 laser. We performed concurrent histopathological study for complete removal of malignant cells and prevention of local recurrence as well as preservation of marginal normal tissue and consequently prevention of complications such as ectropion. The anatomic distortion and scar induced following incomplete excision and repair of primary BCC obscure the malignant cells, which leads to recurrence and identification of tumor margin becomes more difficult [30, 31]. One of the main advantages of this form of therapy in contrast to surgical excision is that it induces no anatomic distortion. Therefore, any remaining malignant cells during laser therapy do not result in irregular growth of malignant cells; it even results in easy and early detection and extent of tumor [20]. BCC on the periorbital area not only is considered a high risk tumor [1–5] but also is associated with a number of complications such as ectropion, trichiasis, and damage to eyelash after surgical

excision [32, 33]. In our method, the recurrence rate was reported in 1 (4.8%) lesion, which occurred in a BCC on the medial canthal lesion, infiltrative histopathological subtype with 20mm diameter. Damage to eyelash was seen in 2 (10%) patients, one in the lower lid with infiltrative pathologic subtype and another in medial canthal BCC, both of which had a diameter more than 10mm. Therefore, patients need to be informed about the probability of eyelash damage in periorbital BCC with high risk infiltrative pathologic subtype and diameter more than 10mm. 5. Conclusion Our study indicated recurrence occurring in one case of nodular clinical type with 20mm diameter and infiltrative histopathological subtype in the medial canthal lesion. Therefore, this method is an appropriate modality for

small, other than inner canthal region, and nonhigh risk histopathological subtype but should be used with caution for large and high risk histopathological subtype in the medial canthal region. Acknowledgment The authors thank the patient for agreeing Brefeldin_A to publish his photo in the paper. Conflict of Interests The authors declare that there is no conflict of interests regarding the publication of this paper.
In recent years, several studies have demonstrated the efficacy of diverse biomedical interventions to prevent the acquisition of human immunodeficiency virus (HIV).1–6 Major developments in the field of prevention of sexual transmission of HIV include male circumcision,1–3 the use of antiretrovirals before exposure to HIV (preexposure prophylaxis [PrEP]),4,7–9 and HIV viral suppression of HIV-infected individuals (treatment as prevention).